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Best Nootropics & Brain Health (2026)

Cognitive enhancement and brain health supplements

29 products reviewed and ranked · Updated February 2026

Our #1 Pick

NOW Foods L-Theanine 200mg

NOW Foods · $14-18 · Capsule

"Calm focus without drowsiness — 200mg L-Theanine with Inositol"

NOW Foods L-Theanine is the best value in the calm-focus category. The 200mg dose is well-studied for promoting alpha brain waves and reducing stress without sedation. The classic biohacker stack is 200mg L-Theanine + 100mg caffeine (one cup of coffee) — try it before buying expensive nootropic blends.

Full Rankings

#	Product	Price	Amazon	Rating
1	NOW Foods L-Theanine 200mg NOW Foods · Capsule	$14-18	4.5 22,000+	8.5
2	Real Mushrooms Lion's Mane Extract Real Mushrooms · Capsule	$28-34	4.5 12,000+	8.8
3	Real Mushrooms Lion's Mane Extract Real Mushrooms · Capsule	$26-34	4.6 10,000+	9.0
4	Nootropics Depot Alpha-GPC 300mg Nootropics Depot · Capsule	$22-28	4.5 8,000+	8.0
5	Genius Mushrooms — Lion's Mane, Cordyceps, Reishi The Genius Brand · Capsule	$22-28	4.4 25,000+	7.5
6	Gorilla Mind Smooth Gorilla Mind · Capsule	$38-45	4.3 5,000+	7.8
7	NOW Foods L-Theanine 200mg NOW Foods · Capsule	$14-18	4.6 15,000+	8.7
8	NOW L-Theanine 200mg Double Strength (120 Veg Capsules) NOW Foods · Veg Capsule	$16-22	4.6 19,400+	8.9
9	Real Mushrooms Lion's Mane Extract (120 Capsules) Real Mushrooms · Capsule	$28-34	4.5 8,200+	8.5
10	NOW L-Theanine 200mg (120 Veg Capsules) NOW Foods · Veg Capsule	$18-24	4.6 18,200+	8.6
11	Four Sigmatic Lion's Mane Mushroom Coffee Four Sigmatic · Instant Coffee Packets	$14-18	4.3 18,000+	7.2
12	Onnit Alpha Brain Onnit · Capsule	$55-68	4.3 25,000+	6.5
13	Host Defense Lion's Mane Capsules Host Defense (Fungi Perfecti) · Capsule	$22-28	4.4 18,000+	7.8
14	Host Defense Lion's Mane Capsules Host Defense · Capsule	$22-28	4.4 15,000+	7.8
15	NOW Foods L-Tyrosine 500mg (120 Capsules) NOW Foods · Capsule	$10-14	4.5 12,000+	7.8
16	NOW Alpha-GPC 300mg (60 Veg Capsules) NOW Foods · Veg Capsule	$22-28	4.5 8,200+	8.5
17	Onnit Alpha Brain (90 Capsules) Onnit · Capsule	$58-66	4.3 22,400+	8.2
18	Onnit Alpha BRAIN Onnit · Capsule	$55-68	4.4 25,000+	7.9
19	Prevagen Regular Strength 10mg Prevagen · Capsule	$32-40	4.2 18,000+	4.5
20	Life Extension Acetyl-L-Carnitine 500mg (100 Capsules) Life Extension · Capsule	$16-22	4.6 3,800+	7.8
21	NOW Acetyl-L-Carnitine 500mg (200 Capsules) NOW Foods · Capsule	$22-28	4.6 12,200+	8.4
22	NOW Phosphatidylserine 100mg (120 Veg Capsules) NOW Foods · Veg Capsule	$28-34	4.5 8,200+	8.5
23	Genius Mushrooms The Genius Brand · Capsule	$18-24	4.4 22,000+	8.3
24	NOW Foods GABA 750mg NOW Foods · Capsule	$12-16	4.5 15,000+	7.8
25	Host Defense Lion's Mane Capsules (120 Count) Host Defense · Capsule	$28-34	4.4 18,200+	8.2
26	NOW GABA 750mg (200 Veg Capsules) NOW Foods · Veg Capsule	$16-22	4.5 18,200+	8.3
27	Host Defense Lion's Mane (60 Capsules) Host Defense · Capsule	$28-34	4.4 12,200+	8.3
28	KAL Lithium Orotate 5mg (120 Capsules) KAL · Capsule	$12-16	4.5 8,200+	8.1
29	Ancestral Supplements Grass Fed Brain Ancestral Supplements · Capsule	$42-52	4.4 3,200+	7.4

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