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#6 in Nootropics & Brain Health Third-Party Tested

Host Defense Lion's Mane Capsules (120 Count)

by Host Defense

"Paul Stamets' lion's mane — the mycologist-formulated brain mushroom for NGF and cognitive support"

Amazon Rating
4.4/5
Reviews
18,200+
Price Range
$28-34
Servings
60 servings
USDA OrganicNon-GMO Project VerifiedGluten Free
Our Editorial Rating
8.2
Very Good
FormCapsule
SubcategoryLion's Mane Mushroom (Mycelium, Paul Stamets)
View on Amazon

Overview

Host Defense Lion's Mane is formulated by world-renowned mycologist Paul Stamets. The product uses mycelium grown on organic brown rice, which is controversial in the mushroom supplement space — purists prefer fruiting body extracts. However, Stamets argues that mycelium contains unique compounds (erinacines) that fruiting bodies lack, and his research supports this. Lion's mane stimulates Nerve Growth Factor (NGF) production, supporting brain health, memory, and nerve regeneration.

Key Ingredients

IngredientAmount
Lion's Mane Mycelium (Organic)1g per serving
Erinacines (from Mycelium)Included
HericenonesIncluded

Pros & Cons

What We Like

  • Formulated by Paul Stamets
  • 18,200+ reviews, 4.4 stars
  • USDA Organic certified
  • NGF stimulation support
  • 120 capsules = 2-month supply

What Could Be Better

  • Mycelium-on-grain (not fruiting body)
  • Contains rice substrate
  • Beta-glucan content debated
  • Premium vs fruiting body alternatives

Who Is This For?

Best For

  • Paul Stamets brand followers
  • Those trusting mycelium research
  • Cognitive support seekers
  • Organic mushroom supplement needs

Not Ideal For

  • Fruiting body purists
  • Those wanting high beta-glucan content
  • Those avoiding grain-based products

Our Verdict

8.2/10 — Very Good

The mycologist's lion's mane. Paul Stamets' reputation backs this product, though the mycelium-vs-fruiting-body debate continues. If you trust Stamets' research on erinacines, this is the choice.

Alternatives to Consider

No direct alternatives listed for this product yet.