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#5 in Nootropics & Brain Health

Prevagen Regular Strength 10mg

by Prevagen

"Apoaequorin-based brain supplement — the most advertised nootropic in America"

Amazon Rating
4.2/5
Reviews
18,000+
Price Range
$32-40
Servings
30 capsules
Drug Free
Our Editorial Rating
4.5
Average
FormCapsule
SubcategoryBrain Health
View on Amazon

Overview

Prevagen contains 10mg of apoaequorin, a protein originally discovered in jellyfish (Aequorea victoria). Prevagen is one of the most heavily advertised brain supplements in the US, with TV commercials claiming it supports brain function and memory. However, the clinical evidence is controversial — the company's own clinical trial failed its primary endpoints, and the FTC filed a lawsuit alleging deceptive advertising (which was partially settled).

Key Ingredients

IngredientAmount
Apoaequorin10mg

Pros & Cons

What We Like

  • 18,000+ reviews — widely used
  • Single ingredient — simple formula
  • Widely available in pharmacies
  • Some users report subjective benefits
  • No stimulants
  • Well-tolerated

What Could Be Better

  • Clinical trial failed primary endpoints
  • FTC lawsuit over advertising claims
  • Apoaequorin is likely digested in the stomach
  • Premium pricing for questionable evidence
  • No evidence it crosses the blood-brain barrier
  • Better-studied alternatives exist

Who Is This For?

Best For

  • Those who have tried it and feel it works for them
  • People wanting a non-stimulant brain supplement

Not Ideal For

  • Evidence-based supplement buyers
  • Budget-conscious consumers
  • Those wanting clinically proven nootropics

Our Verdict

4.5/10 — Average

Prevagen is one of the most controversial supplements on the market. The massive advertising budget doesn't match the clinical evidence — the company's own trial failed its primary endpoints. Apoaequorin is a protein that's likely digested in the stomach before reaching the brain. Better-studied options include omega-3s, phosphatidylserine, and lion's mane mushroom.

Alternatives to Consider