Milk Thistle (Silymarin)
Renowned herbal extract for comprehensive liver support and detoxification.
Also known as: Silybum marianum • Silymarin • Carduus marianus
Overview
Milk Thistle is a flowering herb whose seeds contain the active compound complex, Silymarin. It has been used for centuries for its potent liver-protective, antioxidant, and anti-inflammatory properties, primarily supporting liver cell regeneration and shielding it from toxins.
Key Benefits
Liver Protection
Protects liver cells from damage caused by toxins, alcohol, and certain medications by stabilizing cell membranes.
Promotes Liver Regeneration
Stimulates protein synthesis in liver cells, which helps to regenerate damaged liver tissue.
Antioxidant Power
Silymarin is a powerful antioxidant that helps to neutralize free radicals, reducing oxidative stress in the liver and throughout the body.
Supports Detoxification
Enhances the liver's natural detoxification pathways, aiding in the elimination of harmful substances.
Dosage & How to Take
A standard dose is 150-200mg of Silymarin, taken 1-3 times per day.
| Purpose | Dose | Notes |
|---|---|---|
| General Liver Health | 150-300mg Silymarin/day | Often taken in divided doses. |
| Toxin-Induced Liver Damage | 420-700mg Silymarin/day | Higher doses may be used under medical supervision. |
Best Time to Take
Best taken with food to minimize potential gastrointestinal upset and improve absorption.
With or Without Food
Yes, recommended.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Extract | High | Liver support | Look for extracts standardized to 80% Silymarin for best results. |
| Phosphatidylcholine Complex | Very High | Enhanced absorption | Silymarin bound to phosphatidylcholine (Siliphos) shows superior bioavailability. |
Side Effects & Safety
Common
- Mild gastrointestinal upset
- Diarrhea
- Bloating
Rare
- Allergic reactions (especially in those with ragweed allergies)
Contraindications
- Pregnancy and breastfeeding (consult a doctor)
- Hormone-sensitive conditions (e.g., breast cancer) due to possible estrogenic effects.
Interactions
May decrease the metabolism of drugs like warfarin.
May lower blood sugar levels, requiring dose adjustments.
Scientific Research
Silymarin in non-alcoholic fatty liver disease
Systematic reviews show Silymarin improves liver enzymes (ALT and AST) in patients with NAFLD.
Food Sources
Products With Milk Thistle (Silymarin)
2 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.