Pantethine (Active B5)

The active form of vitamin B5 that supports healthy cholesterol levels and energy production.

Also known as: Pantesin • Coenzyme A precursor

other Names
Pantesin, Coenzyme A precursor
primary Benefits
Supports healthy cholesterol levels, energy production
common Dose
300-900mg per day
best Form
Softgels
timing
With meals
safety Rating
Generally safe for most people

Overview

Pantethine is the active, metabolic form of pantothenic acid (vitamin B5). It is a precursor to coenzyme A, which is essential for energy production and the metabolism of fats, carbohydrates, and proteins. Pantethine has been shown to support healthy cholesterol and triglyceride levels.

Key Benefits

Supports Healthy Cholesterol Levels

Pantethine has been shown to lower LDL (bad) cholesterol and triglycerides, while raising HDL (good) cholesterol.

Enhances Energy Production

As a precursor to coenzyme A, pantethine is essential for the production of ATP, the body's main source of energy.

Supports Adrenal Function

Pantethine is involved in the production of adrenal hormones, which are important for managing stress.

Dosage & How to Take

The recommended dose of pantethine is 300-900mg per day, taken in divided doses with meals.

PurposeDoseNotes
Cholesterol Support600-900mg dailyTaken in two or three divided doses.
Energy Production300-600mg dailyTaken with meals.

Best Time to Take

It is best to take pantethine with meals to enhance absorption.

With or Without Food

Take with food.

Forms & Bioavailability

FormAbsorptionBest ForNotes
SoftgelsHighGeneral useEasy to swallow and well-absorbed.

Side Effects & Safety

Common

  • None reported in most people.

Rare

  • Mild digestive upset, such as nausea and heartburn.

Contraindications

  • None known.

Interactions

None knownMild

Pantethine is not known to interact with any medications or supplements.

Scientific Research

2014Nutrition Research

Pantethine, a derivative of vitamin B5, favorably alters total, LDL, and non-HDL cholesterol in low to moderate cardiovascular risk subjects: a triple-blinded, placebo-controlled, randomized clinical trial

Pantethine supplementation was found to be effective in lowering LDL cholesterol and non-HDL cholesterol in subjects with low to moderate cardiovascular risk.

Food Sources

Beef, chicken, organ meats, egg yolks, and whole grains

Products With Pantethine (Active B5)

1 product in our database contains this ingredient

Frequently Asked Questions

Medical Disclaimer

This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.