Red Yeast Rice
A fermented rice product that naturally contains compounds, including monacolin K, which help maintain healthy cholesterol levels.
Also known as: RYR • Monascus purpureus
Overview
Red Yeast Rice is made by fermenting rice with a type of yeast called Monascus purpureus. This process produces a variety of compounds, most notably monacolin K, which is chemically identical to the active ingredient in the prescription drug lovastatin. As such, RYR is a popular natural alternative for supporting healthy cholesterol levels. It also contains other beneficial substances like sterols, isoflavones, and monounsaturated fatty acids.
Key Benefits
Reduces LDL Cholesterol
The monacolin K in RYR inhibits HMG-CoA reductase, an enzyme responsible for cholesterol production in the liver.
Lowers Triglycerides
Some studies show that RYR can also lead to a modest reduction in triglyceride levels.
Dosage & How to Take
1200-2400 mg daily, providing 5-10 mg of monacolin K.
| Purpose | Dose | Notes |
|---|---|---|
| Cholesterol Support | 1200-2400 mg/day | Choose products that specify the amount of monacolin K and are tested to be free of citrinin, a potential kidney toxin. |
Best Time to Take
Best taken with the evening meal, as cholesterol synthesis is highest at night.
With or Without Food
Yes, take with food to enhance absorption and reduce potential gastrointestinal side effects.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Extract | Good | Cholesterol management | Quality varies significantly between brands. Third-party testing for monacolin K and citrinin is crucial. |
Side Effects & Safety
Common
- Heartburn
- Gas
- Dizziness
Rare
- Muscle pain or weakness (myopathy)
- Liver enzyme elevation
Contraindications
- Liver disease
- Pregnancy
- Breastfeeding
- Concurrent use of statin drugs
Interactions
Increased risk of myopathy and other side effects
Can increase the concentration of monacolin K, raising the risk of side effects
RYR may deplete CoQ10 levels; supplementation is often recommended
Scientific Research
Red yeast rice for dyslipidemia in statin-intolerant patients: a randomized controlled trial
RYR was well tolerated and significantly reduced LDL-C levels in patients who could not tolerate statin therapy.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.