Nattokinase
An enzyme from fermented soybeans that supports cardiovascular health.
Also known as: NK
Overview
Nattokinase is a powerful enzyme extracted and purified from a traditional Japanese food called natto. Natto is made from soybeans fermented with Bacillus subtilis. For centuries, it has been used as a folk remedy for heart and vascular diseases. The enzyme is produced when the bacterium acts on the soybeans. While other soy foods contain enzymes, only natto preparation contains the specific nattokinase enzyme. Its primary and most studied benefit is its fibrinolytic activity, meaning it can help to break down blood clots. This can have significant implications for cardiovascular health, as blood clots can obstruct blood flow and lead to serious events like heart attack and stroke. Nattokinase is also believed to have a positive impact on blood pressure, cholesterol levels, and overall circulation. It is a popular dietary supplement for those looking to support their cardiovascular system naturally.
Key Benefits
Supports Cardiovascular Health
Nattokinase helps to break down fibrin, a protein involved in blood clotting, which can improve circulation and reduce the risk of clot-related issues.
May Lower Blood Pressure
Some studies suggest that nattokinase may have a modest blood pressure-lowering effect, which can contribute to overall cardiovascular wellness.
Improves Blood Flow
By reducing the viscosity of the blood and breaking down clots, nattokinase can enhance circulation throughout the body.
Dosage & How to Take
The standard dose for nattokinase is measured in fibrinolytic units (FU), with 2,000 FU being a common starting point.
| Purpose | Dose | Notes |
|---|---|---|
| General cardiovascular support | 2,000 FU per day | Can be taken in a single dose or divided. |
| More intensive support | Up to 4,000 FU per day | Higher doses should be discussed with a healthcare provider. |
Best Time to Take
For optimal absorption, it is best to take nattokinase on an empty stomach.
With or Without Food
Should be taken without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Capsules | High | General use | Enteric-coated capsules are preferred to protect the enzyme from stomach acid. |
| Powder | Medium | Mixing into drinks | May be less effective if not protected from stomach acid. |
Side Effects & Safety
Common
- None reported in most studies
Rare
- Allergic reactions in individuals with soy allergies
Contraindications
- Bleeding disorders, upcoming surgery, and use of blood-thinning medications.
Interactions
Increased risk of bleeding
May enhance the effect of these drugs
Scientific Research
Nattokinase for prevention of thrombosis
Nattokinase has potent fibrinolytic activity and may be a useful tool for the prevention of thrombosis.
Effects of nattokinase on blood pressure
A meta-analysis of clinical trials found that nattokinase supplementation resulted in a significant reduction in both systolic and diastolic blood pressure.
Food Sources
Products With Nattokinase
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.