Serrapeptase
A proteolytic enzyme that may help to reduce inflammation, pain, and mucus.
Also known as: Serratiopeptidase
Overview
Serrapeptase is an enzyme isolated from a species of bacteria found in the gut of silkworms. It is a proteolytic enzyme, meaning it breaks down proteins. In the body, serrapeptase is thought to help break down non-living tissue, such as scar tissue, blood clots, and mucus, which may help to reduce inflammation and pain.
Key Benefits
Reduces Inflammation
Serrapeptase may help to reduce inflammation by breaking down inflammatory mediators.
Alleviates Pain
By reducing inflammation, serrapeptase can help to alleviate pain associated with conditions like arthritis and sinusitis.
Thins Mucus
Serrapeptase can help to break down mucus, making it easier to clear from the respiratory tract.
Dosage & How to Take
Serrapeptase is measured in milligrams (mg) or units of activity (SPUs or SUs). It should be taken on an empty stomach to ensure it is not broken down by stomach acid.
| Purpose | Dose | Notes |
|---|---|---|
| General Inflammation | 10-20 mg (20,000-40,000 SPU) three times daily | Take at least 30 minutes before or 2 hours after a meal. |
| Chronic Respiratory Diseases | 30 mg daily | Studies have used this dosage for up to 4 weeks. |
Best Time to Take
Must be taken on an empty stomach, at least 30 minutes before or 2 hours after eating.
With or Without Food
Should not be taken with food, as the enzyme may be denatured by stomach acid.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Enteric-Coated Tablets/Capsules | High | Protecting the enzyme from stomach acid. | This is the most effective form. |
Side Effects & Safety
Common
- Nausea
- Stomach pain
- Diarrhea
Rare
- Skin rash
- Pneumonitis (lung inflammation) in elderly patients
Contraindications
- Individuals with bleeding disorders or those taking blood-thinning medications should use with caution.
Interactions
May increase the risk of bleeding.
Serrapeptase may increase the concentration of antibiotics in the tissues.
Scientific Research
A multi-centre, double-blind, randomised, placebo-controlled study of serratiopeptidase in the treatment of patients with acute or chronic sinusitis.
Serratiopeptidase was effective in reducing the severity of symptoms in patients with sinusitis.
The effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.
Serrapeptase was effective in reducing swelling and pain after dental surgery.
Food Sources
Products With Serrapeptase
6 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.