Magnesium L-Threonate
A unique form of magnesium that effectively crosses the blood-brain barrier to support cognitive function and mood.
Also known as: Magtein
Overview
Magnesium L-Threonate is a patented compound that combines magnesium with L-threonic acid, a metabolite of vitamin C. This specific form was developed by scientists at MIT and is unique in its ability to readily cross the blood-brain barrier and increase magnesium concentrations in the brain. This makes it particularly effective for enhancing memory, learning, and reducing anxiety and stress-related symptoms.
Key Benefits
Enhances Cognitive Function
By increasing brain magnesium levels, it supports synaptic plasticity, which is crucial for learning and memory.
Reduces Anxiety and Fear
Studies show it can reduce fear memories and increase feelings of calmness by modulating NMDA receptor activity in the brain.
Improves Sleep Quality
Magnesium has a relaxing effect on the nervous system, and this form's brain-specific action can be particularly helpful for sleep.
Dosage & How to Take
The typical dose is 2000mg of Magnesium L-Threonate per day, which provides 144mg of elemental magnesium. It is often split into a daytime and evening dose.
| Purpose | Dose | Notes |
|---|---|---|
| Cognitive Support | 2000mg/day | Split into two doses (e.g., one capsule mid-day, two before bed). |
| Anxiety & Sleep | 1000-2000mg/day | Primarily taken in the evening. |
Best Time to Take
For cognitive benefits, divided doses are good. For sleep and relaxation, taking the full dose 1-2 hours before bed is effective.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Magnesium L-Threonate (as Magtein®) | Excellent (for brain) | Cognitive and mood support | This is the patented, clinically studied form. It is the only one proven to significantly raise brain magnesium levels. |
Side Effects & Safety
Common
- Drowsiness or sleepiness, especially initially
- Headaches (uncommon)
Rare
- None reported at standard doses
Contraindications
- Severe kidney impairment
Interactions
Magnesium can interfere with the absorption of these drugs. Take at least 2 hours apart.
Magnesium can reduce the absorption of these osteoporosis drugs.
Scientific Research
Enhancement of learning and memory by elevating brain magnesium.
Increasing brain magnesium using a newly developed magnesium compound (magnesium-L-threonate, MgT) can enhance synaptic plasticity, learning, and memory.
Food Sources
Products With Magnesium L-Threonate
61 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.