Apigenin

A flavonoid with calming and antioxidant properties.

Also known as: 4′,5,7-Trihydroxyflavone

other Names
4′,5,7-Trihydroxyflavone
primary Benefits
Sleep support, anxiety relief, antioxidant
common Dose
50-100 mg per day
best Form
Capsules or as a component of chamomile extract
timing
30-60 minutes before bedtime for sleep
safety Rating
Generally Safe

Overview

Apigenin is a flavonoid, a type of plant compound, that is found in many fruits, vegetables, and herbs. It is particularly abundant in chamomile, parsley, and celery. Apigenin is known for its calming and relaxing properties, and it is often used as a natural sleep aid. It is believed to work by binding to certain receptors in the brain that are involved in promoting sleep and reducing anxiety. In addition to its calming effects, apigenin is also a potent antioxidant and has anti-inflammatory properties. It has been studied for a wide range of potential health benefits, including its ability to protect against chronic diseases, such as heart disease and cancer. Some research also suggests that apigenin may have neuroprotective effects and could be beneficial for brain health. However, more studies are needed to fully understand the effects of apigenin and to determine the optimal dosage for various conditions.

Key Benefits

Promotes Sleep

Apigenin has a calming effect on the brain and may help improve sleep quality.

Reduces Anxiety

By binding to certain receptors in the brain, apigenin may help reduce feelings of anxiety.

Powerful Antioxidant

Apigenin helps protect the body from damage caused by free radicals.

Dosage & How to Take

Start with a low dose and gradually increase as needed. Consult with a healthcare professional for personalized advice.

PurposeDoseNotes
Sleep Support50-100 mgTake 30-60 minutes before bedtime.
Anxiety Relief50-100 mg per dayMay be taken in divided doses.

Best Time to Take

For sleep, take before bedtime. For anxiety, it can be taken at any time of day.

With or Without Food

Can be taken with or without food.

Forms & Bioavailability

FormAbsorptionBest ForNotes
CapsulesMediumConvenienceEasy to take and dose.
Chamomile ExtractMediumA natural source of apigeninOften standardized to a certain percentage of apigenin.

Side Effects & Safety

Common

  • Drowsiness

Rare

  • Allergic reactions (in individuals with allergies to the daisy family)

Contraindications

  • Pregnancy and breastfeeding.

Interactions

SedativesModerate

May increase the sedative effects of these medications

Scientific Research

2013Journal of Ethnopharmacology

A preliminary investigation of the sleep-modulatory activity of apigenin

Apigenin may have a role in promoting sleep.

2019Phytotherapy Research

Apigenin and its impact on the central nervous system

A review of the neuroprotective and anxiolytic effects of apigenin.

Food Sources

Chamomile
Parsley
Celery

Products With Apigenin

5 products in our database contain this ingredient

Frequently Asked Questions

Medical Disclaimer

This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.