Indole-3-Carbinol
A compound found in cruciferous vegetables that supports hormone balance.
Also known as: I3C
Overview
Indole-3-carbinol (I3C) is a compound that is produced when you eat cruciferous vegetables like broccoli, cauliflower, and cabbage. When you digest these vegetables, I3C is converted into another compound called diindolylmethane (DIM). Both I3C and DIM are believed to have health benefits, particularly in regard to hormone balance. They are thought to work by promoting the metabolism of estrogen into its beneficial forms, rather than its harmful forms. This may help to reduce the risk of hormone-related cancers, such as breast, cervical, and prostate cancer. I3C and DIM are also being studied for their potential to reduce inflammation, support the immune system, and protect against liver damage.
Key Benefits
Supports Hormone Balance
I3C may help to promote the healthy metabolism of estrogen, which can support hormone balance in both men and women.
May Reduce Cancer Risk
By promoting the beneficial metabolism of estrogen, I3C may help to reduce the risk of hormone-related cancers.
Supports Detoxification
I3C may help to support the liver's detoxification pathways.
Dosage & How to Take
A typical dose of I3C is 200-400 mg per day.
| Purpose | Dose | Notes |
|---|---|---|
| Hormone Balance | 200-400 mg per day | Taken in one or two doses. |
| Cancer Prevention | 400 mg per day | Taken under the supervision of a healthcare provider. |
Best Time to Take
Can be taken daily with meals.
With or Without Food
Best taken with food to improve absorption.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Capsules | Medium | Convenience. | Look for a reputable brand that uses high-quality ingredients. |
Side Effects & Safety
Common
- Skin rashes
- nausea
- dizziness
Rare
- Tremor
- balance problems
Contraindications
- Avoid if you are pregnant or breastfeeding.
Interactions
I3C may affect estrogen levels, so it could interact with medications that are sensitive to estrogen.
Scientific Research
I3C and cancer prevention
A review of studies found that I3C has shown promise as a cancer-preventive agent.
I3C and hormone balance
Studies have shown that I3C can help to promote the healthy metabolism of estrogen.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.