Calcium D-Glucarate
Supports the body's natural detoxification processes, particularly for hormones and toxins.
Also known as: CDG
Overview
Calcium D-Glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by the body and found in many fruits and vegetables. Its primary role is to support glucuronidation, a major Phase II detoxification pathway in the liver. By inhibiting the enzyme beta-glucuronidase, Calcium D-Glucarate helps ensure that toxins and excess hormones (like estrogen) that have been bound for elimination are safely excreted from the body instead of being reabsorbed.
Key Benefits
Promotes Healthy Estrogen Metabolism
Helps the body excrete excess estrogen, which is beneficial for conditions of estrogen dominance like PMS, fibroids, and endometriosis.
Supports Liver Detoxification
Enhances the glucuronidation pathway, which is responsible for detoxifying many hormones, carcinogens, and drugs.
Aids in Toxin Removal
Prevents the reabsorption of toxins that have been processed by the liver, ensuring they are eliminated from the body.
May Lower Cholesterol
Some preliminary evidence suggests it may help lower LDL cholesterol levels.
Dosage & How to Take
Often used in combination with other supplements for hormonal balance, like DIM.
| Purpose | Dose | Notes |
|---|---|---|
| Estrogen Balance/Detox | 200-500 mg/day | Can be split into two doses. |
| Intensive Support | Up to 1000 mg/day | Higher doses may be used under practitioner guidance. |
Best Time to Take
Best taken with meals to minimize any potential stomach upset.
With or Without Food
Yes, take with food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Calcium D-Glucarate Capsules | Good | General detox and hormone support | This is the standard and most studied form. |
Side Effects & Safety
Common
- Generally very well-tolerated.
Rare
- Mild digestive upset in sensitive individuals.
Contraindications
- None known, but consult a doctor if pregnant or breastfeeding.
Interactions
Theoretically, it could increase the elimination rate of certain drugs (e.g., some statins, benzodiazepines), potentially reducing their effectiveness. Consult a doctor.
Scientific Research
Calcium-D-glucarate
A review noted that D-glucarate has been shown to inhibit beta-glucuronidase, and animal studies suggest it may inhibit cancer by enhancing the removal of carcinogens.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.