Astragaloside IV
A key active compound from Astragalus root that supports telomere health and slows cellular aging.
Also known as: AG-IV • Astragalus membranaceus extract
Overview
Astragaloside IV is a saponin that is considered one of the most important active ingredients in the traditional Chinese herb Astragalus membranaceus. It is most famous for its ability to activate telomerase, the enzyme responsible for maintaining the length of telomeres. Telomeres are protective caps at the ends of our chromosomes that shorten with each cell division. By slowing this shortening process, Astragaloside IV may help to slow down cellular aging and enhance immune function.
Key Benefits
Telomerase Activation
Astragaloside IV has been shown to activate telomerase, which helps to maintain or even lengthen telomeres, a key biomarker of cellular aging.
Immune System Modulation
It enhances the activity of various immune cells, helping to bolster the body's defenses against pathogens.
Cardioprotective and Anti-inflammatory
It protects the cardiovascular system by reducing inflammation and oxidative stress in blood vessels.
Dosage & How to Take
5-10 mg per day of a purified Astragaloside IV extract.
| Purpose | Dose | Notes |
|---|---|---|
| General Anti-Aging and Immune Support | 5 mg/day | A common dose for daily maintenance. |
| Targeted Telomere Support | 10 mg/day | A higher dose used in more focused anti-aging protocols. |
Best Time to Take
Can be taken anytime, with or without food.
With or Without Food
Not required, but can be taken with a meal.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Astragaloside IV Extract | Low. It is a large molecule with poor oral absorption. | General use. | Look for extracts specifying the exact mg of Astragaloside IV, not just Astragalus root powder. |
| Cycloastragenol | Higher. It is a smaller, more bioavailable molecule derived from Astragaloside IV. | More potent telomerase activation. | Often significantly more expensive. |
| Liposomal Astragaloside IV | Significantly enhanced. The liposomal delivery system protects the molecule and improves absorption. | Maximizing effectiveness. | A premium and more effective option. |
Side Effects & Safety
Common
- Very well-tolerated. Astragalus root has been used safely for centuries.
Rare
- May overstimulate the immune system in those with autoimmune conditions.
Contraindications
- Individuals with autoimmune diseases (e.g., rheumatoid arthritis, lupus) should use with caution. Pregnant women should avoid it.
Interactions
May counteract the effects of drugs designed to suppress the immune system.
Scientific Research
Astragaloside IV and its pharmacological effects
A review detailing the anti-inflammatory, anti-oxidative, and anti-aging effects of Astragaloside IV, highlighting its role in telomerase activation.
Telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice
A study on a proprietary Astragalus extract (TA-65) showed it could lengthen short telomeres and improve health markers in mice, supporting the telomere hypothesis of aging.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.