Trans-Resveratrol
A powerful polyphenol antioxidant that activates sirtuins and mimics calorie restriction.
Also known as: Resveratrol • Polygonum cuspidatum extract
Overview
Trans-Resveratrol is the most biologically active form of resveratrol, a natural polyphenol found in grapes, berries, and Japanese knotweed. It is renowned for its potent antioxidant properties and its ability to activate SIRT1, a key longevity gene, which helps protect the body against oxidative stress and age-related diseases.
Key Benefits
Sirtuin (SIRT1) Activation
Trans-resveratrol is a well-known activator of SIRT1, a protein that plays a crucial role in cellular health, metabolism, and longevity.
Cardiovascular Support
Its antioxidant properties help protect the cardiovascular system by reducing LDL oxidation and supporting healthy blood flow.
Potent Antioxidant
It neutralizes damaging free radicals, reducing oxidative stress throughout the body, which is a key factor in aging.
Dosage & How to Take
150-500 mg of trans-resveratrol per day.
| Purpose | Dose | Notes |
|---|---|---|
| General Antioxidant Support | 150-250 mg/day | A standard dose for overall health maintenance. |
| Longevity and SIRT1 Activation | 250-500+ mg/day | Higher doses are often used in anti-aging protocols, sometimes in conjunction with NMN. |
Best Time to Take
Can be taken anytime. Taking it with a small amount of fat (like yogurt or olive oil) can improve absorption.
With or Without Food
Recommended to be taken with food, particularly a source of fat, to enhance bioavailability.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standard Trans-Resveratrol | Low. It is rapidly metabolized in the intestines and liver. | General use. | Often sourced from Japanese Knotweed (Polygonum cuspidatum). |
| Micronized Resveratrol | Improved. The particle size is reduced to increase surface area and absorption. | Enhanced effectiveness. | A more advanced and effective form. |
Side Effects & Safety
Common
- Generally well-tolerated. High doses (>1g) may cause mild gastrointestinal upset.
Rare
- Headaches, anxiety. May have estrogenic activity, so caution is advised for hormone-sensitive conditions.
Contraindications
- May interact with blood thinners (e.g., warfarin) and NSAIDs. Pregnant women and those with estrogen-sensitive cancers should consult a doctor.
Interactions
May increase the risk of bleeding due to its anti-platelet activity.
Resveratrol can inhibit certain CYP enzymes, potentially affecting the metabolism of various medications.
Scientific Research
Resveratrol as a sirtuin activator
Studies have shown that resveratrol can directly activate SIRT1, leading to downstream effects that mimic some of the benefits of calorie restriction.
Effects of resveratrol on cardiovascular health
A meta-analysis concluded that resveratrol supplementation can significantly improve systolic blood pressure and other cardiovascular markers.
Food Sources
Products With Trans-Resveratrol
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.