Thorne Methyl-Guard Plus
by Thorne
"Comprehensive methylation support — active folate, B12, B6, B2 for MTHFR variants and homocysteine management"
Overview
Thorne Methyl-Guard Plus provides the four B vitamins essential for methylation in their active, bioavailable forms: 5-MTHF (active folate, 1000mcg), methylcobalamin (active B12, 1000mcg), pyridoxal 5'-phosphate (active B6, 25mg), and riboflavin 5'-phosphate (active B2, 25mg). This formula is specifically designed for individuals with MTHFR gene variants who cannot efficiently convert folic acid to its active form. Proper methylation is essential for DNA repair, neurotransmitter synthesis, detoxification, and homocysteine metabolism.
Key Ingredients
| Ingredient | Amount |
|---|---|
| 5-MTHF (Active Folate) | 1000 mcg |
| Methylcobalamin (Active B12) | 1000 mcg |
| P5P (Active B6) | 25 mg |
| R5P (Active B2) | 25 mg |
Pros & Cons
What We Like
- All active-form B vitamins
- Designed for MTHFR variants
- Thorne practitioner quality
- Comprehensive methylation support
- 5,000+ reviews
What Could Be Better
- Premium price ($38-48)
- Not needed without MTHFR variants
- 90 capsules (1-month at 3/day)
- Requires genetic testing context
Who Is This For?
Best For
- MTHFR gene variant carriers
- Elevated homocysteine
- Methylation optimization
- Practitioner-guided supplementation
Not Ideal For
- Those without MTHFR variants
- Budget B-vitamin seekers
- Those not needing methylation support
Our Verdict
Thorne Methyl-Guard Plus is the gold standard for methylation support — all four active B vitamins for MTHFR variant carriers. Essential for those with genetic methylation impairments. Get tested before supplementing.
Alternatives to Consider
No direct alternatives listed for this product yet.