Nature Made Vitamin D3 + K2 (120 Softgels)
by Nature Made
"5000 IU D3 + 100mcg K2 (MK-7) — the pharmacist-recommended D3+K2 combo for calcium metabolism and bone health with 22,000+ reviews"
Overview
Nature Made Vitamin D3 + K2 provides 5000 IU (125mcg) of vitamin D3 and 100mcg of vitamin K2 (as MK-7) per softgel. This combination addresses a critical synergy: vitamin D3 increases calcium absorption from the intestines, while vitamin K2 (MK-7) activates osteocalcin (which deposits calcium into bones) and matrix Gla protein (which prevents calcium from depositing in arteries). Without adequate K2, supplemental D3 can increase calcium absorption but that calcium may end up in soft tissues (arteries, kidneys) rather than bones. The MK-7 form of K2 has a 72-hour half-life (vs 1-2 hours for MK-4), providing sustained activity from a single daily dose.
Key Ingredients
| Ingredient | Amount |
|---|---|
| Vitamin D3 (Cholecalciferol) | 5000 IU (125 mcg) |
| Vitamin K2 (MK-7) | 100 mcg |
2 ingredients linked to detailed encyclopedia profiles
Pros & Cons
What We Like
- 120 softgels (4-month supply)
- 22,000+ reviews
- D3+K2 synergy
- USP Verified
- Under $18
What Could Be Better
- Lanolin-derived D3 (not vegan)
- 100mcg K2 (some want more)
- May interact with blood thinners
- Single softgel (not scored)
Who Is This For?
Best For
- Bone health
- D3 supplementation with proper K2
- Those wanting calcium metabolism support
- Budget D3+K2 combo
Not Ideal For
- Those on warfarin/blood thinners
- Vegans
- Those wanting higher K2
- Those with adequate D levels
Our Verdict
Nature Made D3+K2 is the pharmacist's bone combo — 5000 IU D3 with 100mcg K2 (MK-7) for proper calcium metabolism. The 22,000+ reviews and USP verification make this the gold standard D3+K2; essential for anyone supplementing D3.
Alternatives to Consider
No direct alternatives listed for this product yet.