Life Extension Optimized Folate (L-Methylfolate)
by Life Extension
"1700mcg DFE L-methylfolate — the bioactive folate for those with MTHFR variants who can't convert folic acid"
Overview
Life Extension Optimized Folate provides 1700mcg DFE of L-5-methyltetrahydrofolate (5-MTHF), the bioactive form of folate that bypasses the MTHFR enzyme. Up to 40% of the population has MTHFR gene variants that reduce the ability to convert synthetic folic acid into its active form. L-methylfolate is immediately usable by the body without any conversion needed. This is critical for methylation, homocysteine metabolism, neurotransmitter synthesis, and DNA repair. Life Extension uses Quatrefolic, a patented glucosamine salt of 5-MTHF with superior stability.
Key Ingredients
| Ingredient | Amount |
|---|---|
| L-5-Methyltetrahydrofolate (Quatrefolic) | 1700 mcg DFE |
Pros & Cons
What We Like
- Bioactive L-methylfolate
- Quatrefolic (patented, stable)
- 100 tablets
- 6,200+ reviews
- Bypasses MTHFR variants
What Could Be Better
- Premium over folic acid
- May not be needed without MTHFR variant
- 1700mcg DFE (high dose)
- Single nutrient
Who Is This For?
Best For
- MTHFR variant carriers
- Those who can't convert folic acid
- Methylation support
- Homocysteine management
Not Ideal For
- Those without MTHFR variants
- Those wanting basic folic acid
- Budget seekers
- Those wanting comprehensive B-complex
Our Verdict
Life Extension Optimized Folate is the MTHFR solution — Quatrefolic L-methylfolate bypasses the genetic bottleneck that affects up to 40% of people. Essential for anyone who has tested positive for MTHFR variants.
Alternatives to Consider
No direct alternatives listed for this product yet.