Life Extension Optimized Folate (L-Methylfolate) 1700mcg DFE (100 Tablets)
by Life Extension
"Bioactive 5-MTHF folate for MTHFR carriers — bypasses the methylation bottleneck"
Overview
Life Extension Optimized Folate provides 1700mcg DFE of 5-methyltetrahydrofolate (5-MTHF), the bioactive form of folate that bypasses the MTHFR enzyme entirely. An estimated 40-60% of the population carries MTHFR gene variants that reduce the ability to convert folic acid to its active form. This supplement provides the end-product directly, ensuring adequate folate status regardless of genetic variation. The 100-tablet count provides over 3 months of daily supplementation.
Key Ingredients
| Ingredient | Amount |
|---|---|
| 5-MTHF (L-Methylfolate) | 1700 mcg DFE (1000 mcg L-methylfolate) |
Pros & Cons
What We Like
- Bioactive 5-MTHF — bypasses MTHFR
- Essential for 40-60% with MTHFR variants
- 100 tablets = 3+ month supply
- 6,400+ reviews, 4.7 stars
- Life Extension quality
What Could Be Better
- Higher cost than folic acid
- May cause anxiety in some (overmethylation)
- Not needed if MTHFR-normal
- Tablet form only
Who Is This For?
Best For
- MTHFR mutation carriers
- Those not responding to folic acid
- Pregnancy planning (with MD)
- Methylation support
Not Ideal For
- Those without MTHFR variants
- Those prone to overmethylation
- Budget folate seekers
Our Verdict
Essential for the 40-60% of people with MTHFR variants. Bioactive 5-MTHF ensures folate reaches its active form regardless of genetic methylation capacity.
Alternatives to Consider
No direct alternatives listed for this product yet.