Riboflavin-5-Phosphate (Active B2)
The active, readily usable form of Vitamin B2 for energy production and cellular health.
Also known as: R5P • Active Vitamin B2 • Flavin Mononucleotide • FMN
Overview
Riboflavin-5-Phosphate (R5P) is the active, coenzyme form of Vitamin B2. Unlike standard riboflavin, R5P does not need to be converted by the body, allowing for more immediate utilization. It is a crucial component of cellular energy production and the metabolism of fats, drugs, and steroids.
Key Benefits
Supports Energy Metabolism
R5P is a key cofactor for enzymes involved in the Krebs cycle, the body's primary process for generating ATP (energy).
May Help Prevent Migraines
Some studies suggest that high-dose riboflavin supplementation can help reduce the frequency and severity of migraine headaches.
Essential for Red Blood Cell Production
It plays a role in iron metabolism and is necessary for the formation of healthy red blood cells, helping to prevent anemia.
Acts as an Antioxidant
R5P is required to regenerate glutathione, one of the body's most important antioxidants, which helps protect cells from oxidative damage.
Dosage & How to Take
Dosage for R5P can vary based on individual needs. For general health, a lower dose is sufficient, while higher doses may be used for specific conditions like migraines, under the guidance of a healthcare professional.
| Purpose | Dose | Notes |
|---|---|---|
| General Health | 25-50 mg per day | A common dose for maintaining adequate levels. |
| Migraine Prevention | 100-400 mg per day | Higher doses have been used in clinical trials for migraine prophylaxis. |
| Cataract Prevention | 25-50 mg per day | May help protect against oxidative damage in the lens of the eye. |
Best Time to Take
Best taken with food to improve absorption.
With or Without Food
It is recommended to take R5P with a meal containing some fat.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Riboflavin-5-Phosphate | High | Individuals with compromised B-vitamin metabolism or absorption issues. | The active, readily usable form. |
| Riboflavin (Vitamin B2) | Medium | General supplementation in healthy individuals. | Requires conversion in the body to its active form, R5P. |
Side Effects & Safety
Common
- Bright yellow urine (a harmless effect)
- Diarrhea at very high doses
Rare
- Allergic reactions are possible but very uncommon.
Contraindications
- No significant contraindications are known for riboflavin.
Interactions
These medications can decrease the absorption of riboflavin from the diet.
Can increase the absorption of riboflavin and decrease its excretion.
Large amounts of boric acid can increase the excretion of riboflavin.
Scientific Research
High-dose riboflavin treatment for migraine prophylaxis: a randomized, controlled trial
A daily dose of 400 mg of riboflavin was effective in reducing migraine frequency.
Riboflavin (vitamin B-2) and health
Riboflavin is crucial for energy metabolism and the metabolism of fats, carbohydrates, and proteins.
The Role of Riboflavin in Health and Disease
Riboflavin deficiency can lead to a variety of health problems, including skin disorders, hair loss, and anemia.
Food Sources
Products With Riboflavin-5-Phosphate (Active B2)
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.