Fisetin
A potent senolytic flavonoid that helps clear out aging, dysfunctional cells.
Also known as: Cotinus coggygria extract
Overview
Fisetin is a flavonoid and antioxidant found in many fruits and vegetables, with strawberries being a particularly rich source. It has gained significant attention as a senolytic, an agent that can selectively induce the death of senescent (aging) cells. These cells accumulate with age and contribute to inflammation and tissue dysfunction. By clearing them, fisetin may help rejuvenate tissues and promote longevity.
Key Benefits
Senolytic Activity
Fisetin is one of the most potent natural senolytics, helping the body clear out dysfunctional, inflammatory senescent cells that accumulate with age.
Brain Health and Neuroprotection
Studies suggest fisetin can cross the blood-brain barrier and supports cognitive function by reducing oxidative stress and inflammation in the brain.
Antioxidant and Anti-inflammatory
It directly neutralizes free radicals and helps reduce the production of inflammatory cytokines, protecting cells from damage.
Dosage & How to Take
100-200 mg per day for daily support.
| Purpose | Dose | Notes |
|---|---|---|
| Daily Antioxidant Support | 100-200 mg/day | A maintenance dose for general health. |
| Senolytic Therapy (Mayo Clinic Protocol) | 20 mg/kg of body weight for 2 consecutive days | This high-dose protocol is taken periodically (e.g., once a month) and should be done under medical guidance. |
Best Time to Take
Best taken with a meal that contains fat to significantly improve its poor natural bioavailability.
With or Without Food
Strongly recommended. Fisetin is fat-soluble and its absorption is greatly enhanced by fats.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standard Fisetin Extract | Very low. It is poorly absorbed on its own. | Not recommended unless combined with fats. | Often sourced from the smoke tree (Cotinus coggygria). |
| Liposomal or Lipid-formulated Fisetin | Significantly higher. Formulations like Novusetin® or liposomal versions improve absorption by up to 25x. | Effective senolytic and daily use. | The preferred form for achieving therapeutic levels. |
Side Effects & Safety
Common
- Generally well-tolerated. No significant side effects have been reported at standard doses.
Rare
- Unknown in humans. High-dose protocols should be approached with caution.
Contraindications
- Not enough research in pregnant or breastfeeding women. Those on blood-thinning medication should consult a doctor.
Interactions
Theoretically, it may have mild anti-platelet effects, potentially increasing bleeding risk.
Scientific Research
Fisetin is a senotherapeutic that extends health and lifespan
In aged mice, fisetin treatment reduced the burden of senescent cells, restored tissue homeostasis, and extended median and maximum lifespan.
Fisetin as a neuroprotective agent
Preclinical studies show fisetin maintains mitochondrial function in the face of oxidative stress, suggesting a role in protecting against neurodegenerative diseases.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.