Polygala tenuifolia
A traditional Chinese herb used for memory enhancement and emotional well-being.
Also known as: Yuan Zhi • Thinleaf Milkwort • Chinese Senega
Overview
Polygala tenuifolia is a traditional Chinese medicine herb known as Yuan Zhi. It has been used for centuries to calm the mind, improve memory, and support emotional balance. Modern research has identified saponins (tenuifolin, onjisaponin B) as active compounds that promote neurogenesis, enhance BDNF expression, and modulate NMDA receptors.
Key Benefits
Memory Enhancement
Saponins promote synaptic plasticity and enhance long-term potentiation.
Neurogenesis
Stimulates BDNF expression and promotes growth of new neurons.
Mood Support
Traditional use for calming the spirit and reducing anxiety.
Neuroprotection
Protects against amyloid-beta toxicity in preclinical studies.
Dosage & How to Take
100-300 mg standardized extract daily.
| Purpose | Dose | Notes |
|---|---|---|
| General nootropic | 100-200 mg/day | Standardized extract |
| Enhanced cognitive support | 200-300 mg/day | Split into 2 doses |
Best Time to Take
Morning or afternoon.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Extract Capsules | Good | Consistent dosing | Look for standardized saponin content. |
| Powder | Moderate | Traditional preparation | Can be mixed into tea. |
Side Effects & Safety
Common
- Mild GI discomfort
Rare
- Nausea at high doses
Contraindications
- Pregnancy
- Active gastric ulcers
Interactions
May enhance sedative effects.
Scientific Research
Polygala tenuifolia and cognitive function
Animal studies showed improved memory and learning through BDNF upregulation and NMDA receptor modulation.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.