Pepsin
The primary stomach enzyme for protein digestion, often combined with betaine HCl.
Also known as: Pepsin A • Gastric Protease
Overview
Pepsin is the principal digestive enzyme in the stomach, responsible for breaking down proteins into smaller peptides. It is activated by hydrochloric acid and works optimally at pH 1.5-2.5. Supplemental pepsin is commonly combined with betaine HCl.
Key Benefits
Protein Digestion
Breaks down dietary proteins into absorbable peptides and amino acids.
Stomach Acid Support
Works synergistically with HCl to optimize gastric digestion.
Nutrient Absorption
Proper protein digestion improves amino acid and mineral absorption.
Reduces Bloating
Better protein digestion reduces post-meal bloating.
Dosage & How to Take
100-250 mg pepsin with 500-2000 mg betaine HCl per meal.
| Purpose | Dose | Notes |
|---|---|---|
| Mild support | 100 mg pepsin + 500 mg HCl | Per protein meal |
| Moderate support | 200-250 mg pepsin + 1000-2000 mg HCl | Titrate up gradually |
Best Time to Take
At the beginning of protein-containing meals.
With or Without Food
Yes, always with protein-containing meals.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Betaine HCl + Pepsin Capsules | Good | Standard use | Most common combination. |
| Standalone Pepsin Capsules | Good | Custom protocols | Less common. |
Side Effects & Safety
Common
- Warmth in stomach (normal)
Rare
- Stomach irritation
- Heartburn
Contraindications
- Active gastric ulcers
- Gastritis
- NSAID use
Interactions
Combined use may increase stomach irritation risk.
Counteracts acid supplementation purpose.
Scientific Research
Betaine HCl and pepsin for hypochlorhydria
Studies support supplementation for improving protein digestion in low stomach acid.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.