Pancreatic Lipase
A digestive enzyme that breaks down fats into smaller molecules for absorption.
Also known as: Pancrelipase
Overview
Pancreatic lipase is an enzyme produced by the pancreas that is essential for the digestion of fats. It breaks down triglycerides into fatty acids and monoglycerides, which can then be absorbed by the small intestine. Pancreatic lipase supplements are used to treat conditions where the pancreas does not produce enough enzymes, such as cystic fibrosis and chronic pancreatitis.
Key Benefits
Improves Fat Digestion
Helps to break down fats in the diet, which can reduce symptoms of malabsorption such as steatorrhea (fatty stools).
Enhances Nutrient Absorption
By improving fat digestion, it can also help to improve the absorption of fat-soluble vitamins (A, D, E, and K).
Dosage & How to Take
Dosage is based on the amount of lipase units needed per gram of fat consumed. It is important to work with a healthcare provider to determine the correct dosage.
| Purpose | Dose | Notes |
|---|---|---|
| Exocrine Pancreatic Insufficiency | 500-2,500 lipase units/kg per meal | Dosage should be adjusted based on symptoms and fat intake. |
Best Time to Take
Must be taken with meals and snacks.
With or Without Food
Must be taken with food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Enteric-Coated Capsules | High | Protecting the enzyme from stomach acid | Designed to release the enzyme in the small intestine. |
Side Effects & Safety
Common
- Nausea
- Diarrhea
- Stomach cramps
Rare
- Fibrosing colonopathy (with very high doses)
Contraindications
- None known.
Interactions
May decrease the effectiveness of acarbose.
May decrease the absorption of iron.
Scientific Research
Pancreatic Enzyme Replacement Therapy
A review of studies found that pancreatic enzyme replacement therapy is effective in improving fat absorption and reducing symptoms of malabsorption in patients with exocrine pancreatic insufficiency.
Food Sources
Products With Pancreatic Lipase
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.