Vitamin K2 from Natto
A highly bioactive form of Vitamin K2, essential for directing calcium to bones and away from arteries.
Also known as: Menaquinone-7 • MK-7
Overview
Vitamin K2 as Menaquinone-7 (MK-7) is a fat-soluble vitamin most famously found in high concentrations in natto, a traditional Japanese fermented soybean dish. Its primary role is to activate proteins that regulate calcium metabolism. It activates osteocalcin, which helps bind calcium to the bone matrix, and matrix Gla protein (MGP), which helps prevent calcium from depositing in arteries and soft tissues. This dual action makes it critical for both skeletal and cardiovascular health.
Key Benefits
Promotes Bone Health
Activates osteocalcin, a protein that helps incorporate calcium into bones, improving bone density and strength.
Supports Cardiovascular Health
Activates Matrix Gla Protein (MGP) which inhibits calcium from being deposited in artery walls, helping to maintain arterial flexibility.
Improves Dental Health
Osteocalcin, activated by K2, is also involved in stimulating the growth of new dentin, the calcified tissue underneath tooth enamel.
Dosage & How to Take
A daily dose of 90-180 mcg is commonly used for general health.
| Purpose | Dose | Notes |
|---|---|---|
| Bone Support | 180-360 mcg/day | Often combined with Vitamin D3. |
| Cardiovascular Support | 90-180 mcg/day | Long-term supplementation is key. |
Best Time to Take
Take with a meal containing fat to enhance absorption.
With or Without Food
Yes, it is a fat-soluble vitamin.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Menaquinone-7 (MK-7) | High | Bone and cardiovascular health | Has a longer half-life than MK-4, allowing for once-daily dosing. |
| Menaquinone-4 (MK-4) | Lower | More researched for specific bone density applications | Has a very short half-life, requiring multiple doses per day. |
Side Effects & Safety
Common
Rare
Contraindications
- Concurrent use with warfarin (Coumadin) unless directed by a doctor.
Interactions
Vitamin K directly counteracts the effect of warfarin, reducing its anticoagulant efficacy.
Scientific Research
Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women
MK-7 supplementation significantly improved vitamin K status and decreased the age-related decline in bone mineral density.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.