Myo-Inositol
A carbocyclic sugar that plays a key role in insulin signaling and hormonal health.
Also known as: Inositol • Vitamin B8 (unofficial)
Overview
Myo-inositol is a vitamin-like substance, often incorrectly called Vitamin B8. It is a crucial component of cell membranes and a secondary messenger in insulin signaling pathways. It is widely studied for its benefits in improving insulin sensitivity, particularly in conditions like Polycystic Ovary Syndrome (PCOS) and gestational diabetes. It also plays a role in neurotransmitter signaling, affecting mood and mental health.
Key Benefits
Enhances Insulin Signaling
Acts as a secondary messenger, helping cells respond appropriately to insulin, which improves glucose uptake.
Manages PCOS Symptoms
Highly effective for improving insulin resistance, regulating menstrual cycles, and reducing androgen levels in women with PCOS.
Supports Mental Health
Plays a role in the pathways of neurotransmitters like serotonin and dopamine, and has been studied for its benefits in panic disorder, depression, and OCD.
Promotes Metabolic Health
Can help improve triglyceride levels, blood pressure, and overall metabolic syndrome markers.
Dosage & How to Take
Doses are typically in grams, not milligrams.
| Purpose | Dose | Notes |
|---|---|---|
| Insulin Resistance/PCOS | 2-4 g/day | Often taken as 2g in the morning and 2g in the evening. A 40:1 ratio of Myo- to D-chiro-inositol is common. |
| Mood Support (e.g., Panic Disorder) | 12-18 g/day | High doses are used under clinical supervision. |
Best Time to Take
Can be taken anytime. Dividing the dose (e.g., morning and evening) is common for higher amounts.
With or Without Food
Optional. It has a mildly sweet taste and dissolves easily in water.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Myo-Inositol | High | Primary form for insulin sensitivity and mood | The most abundant and researched form. |
| D-Chiro-Inositol (DCI) | High | Used in conjunction with Myo-inositol for PCOS | The body converts Myo-inositol to DCI. Supplementing both in a 40:1 ratio is thought to be optimal for PCOS. |
Side Effects & Safety
Common
- Virtually none at standard doses (2-4g).
Rare
- At very high doses (12g+), mild gastrointestinal effects like gas, nausea, or diarrhea may occur.
Contraindications
- None known.
Interactions
Inositol is considered very safe and does not have significant known drug interactions.
Scientific Research
Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials
This meta-analysis confirmed that myo-inositol supplementation significantly improves metabolic profiles (improving insulin sensitivity) and restores spontaneous ovulation in women with PCOS.
Food Sources
Products With Myo-Inositol
2 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.