Methylfolate
The active form of folate (Vitamin B9), crucial for methylation, neurotransmitter synthesis, and cardiovascular health.
Also known as: L-Methylfolate • 5-MTHF
Overview
Methylfolate, also known as L-methylfolate or 5-MTHF, is the most biologically active form of folate, or vitamin B9. Unlike folic acid, a synthetic form of folate that requires a multi-step conversion process in the body, methylfolate is readily available for use. This is particularly important for individuals with a common genetic mutation in the MTHFR gene, which can impair the body's ability to convert folic acid into its active form. Methylfolate plays a critical role in a fundamental biochemical process called methylation, which is involved in DNA synthesis, neurotransmitter production, and the regulation of homocysteine levels. By supporting methylation, methylfolate contributes to cardiovascular health, mood regulation, and cognitive function. It is often used as a supplement to address folate deficiency and as an adjunct therapy for depression.
Key Benefits
Supports Healthy Mood
Methylfolate is involved in the synthesis of neurotransmitters like serotonin, dopamine, and norepinephrine, which play a key role in mood regulation.
Promotes Cardiovascular Health
By helping to regulate homocysteine levels, methylfolate supports the health of blood vessels and reduces the risk of cardiovascular disease.
Essential for Healthy Pregnancy
Adequate folate levels are crucial for the proper development of the neural tube in a growing fetus, preventing birth defects.
Dosage & How to Take
Dosage can vary widely depending on individual needs and health conditions. It is best to consult with a healthcare provider.
| Purpose | Dose | Notes |
|---|---|---|
| General Health | 400-1000 mcg daily | A common dosage for maintaining adequate folate levels. |
| Adjunctive Treatment for Depression | 7.5-15 mg daily | Higher doses are often used under medical supervision. |
Best Time to Take
Can be taken at any time of day.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| L-5-Methyltetrahydrofolate (L-5-MTHF) | High | Individuals with MTHFR mutations and for general supplementation. | The most active and readily usable form of folate. |
| Folic Acid | Moderate | Fortified foods and some supplements. | A synthetic form that requires conversion in the body. |
Side Effects & Safety
Common
- Nausea
- Stomach upset
- Diarrhea
Rare
- Anxiety
- Insomnia
- Irritability
Contraindications
- Individuals with a history of cancer should consult a doctor before taking high doses of methylfolate.
Interactions
May interfere with the effectiveness of methotrexate.
May decrease the effectiveness of some anticonvulsant drugs.
Scientific Research
L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials
L-methylfolate may be an effective adjunctive therapy for patients with major depressive disorder who have an inadequate response to SSRIs.
The MTHFR C677T polymorphism and cognitive function: a meta-analysis
The MTHFR C677T polymorphism is associated with a modest decrease in cognitive function, and folate supplementation may have a protective effect.
Food Sources
Products With Methylfolate
16 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.