Magnesium Glycinate

A highly bioavailable form of magnesium known for its calming and relaxing properties.

Also known as: Magnesium Bisglycinate • Magnesium Diglycinate

other Names
Magnesium bisglycinate
primary Benefits
Supports sleep, relaxation, and nervous system health.
common Dose
200-400 mg per day
best Form
Chelated glycinate or bisglycinate
timing
Evening or before bedtime
safety Rating
Generally safe, high doses may cause mild digestive upset.

Overview

Magnesium Glycinate is a chelated form of magnesium, bound to the amino acid glycine. This bonding enhances its absorption and makes it gentle on the stomach. It is particularly favored for its ability to support relaxation, improve sleep quality, and reduce anxiety without the laxative effect common to other magnesium forms.

Key Benefits

Improves Sleep Quality

Glycine itself has calming properties, and when combined with magnesium, it promotes deeper, more restorative sleep.

Reduces Anxiety and Stress

Supports the production of GABA, a neurotransmitter that has a calming effect on the brain.

Supports Muscle Relaxation

Helps to relieve muscle tension and cramps by regulating neuromuscular signals.

Dosage & How to Take

200-400 mg of elemental magnesium per day.

PurposeDoseNotes
Sleep Support200-400 mgTaken 30-60 minutes before bed.
Anxiety Relief150-300 mgCan be taken in divided doses throughout the day.

Best Time to Take

Best taken in the evening to promote relaxation and sleep.

With or Without Food

Can be taken with or without food, but taking it with a meal may further reduce any risk of stomach upset.

Forms & Bioavailability

FormAbsorptionBest ForNotes
Magnesium Glycinate PowderHighFlexible dosing and mixing into drinks.May have a slightly sweet taste due to glycine.
Magnesium Glycinate CapsulesHighConvenience and precise dosing.Most common form available.

Side Effects & Safety

Common

  • Generally well-tolerated.

Rare

  • Diarrhea
  • nausea
  • stomach cramps (at very high doses).

Contraindications

  • Individuals with kidney failure should consult a doctor before supplementing with magnesium.

Interactions

Tetracycline antibioticsModerate

Magnesium can decrease the absorption of these drugs.

BisphosphonatesModerate

Absorption of bisphosphonates can be reduced by magnesium.

Scientific Research

2012https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/

The effect of magnesium supplementation on primary insomnia in elderly

Magnesium supplementation appeared to improve subjective measures of insomnia such as ISI score, sleep efficiency, sleep time and sleep onset latency, early morning awakening, and likewise, insomnia objective measures such as concentration of serum renin, melatonin, and serum cortisol, in elderly people.

Food Sources

Spinach
almonds
avocado
dark chocolate
black beans

Products With Magnesium Glycinate

3 products in our database contain this ingredient

Frequently Asked Questions

Medical Disclaimer

This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.