L-Ornithine
A non-essential amino acid that plays a key role in the urea cycle and ammonia detoxification.
Also known as: Ornithine
Overview
L-Ornithine is a non-essential amino acid, meaning the body can produce it on its own. It plays a central role in the urea cycle, a metabolic process that converts toxic ammonia into urea, which is then excreted in the urine. This detoxification process is crucial for preventing the buildup of ammonia in the body, which can be harmful to the brain and nervous system. Ornithine works in conjunction with arginine and citrulline to facilitate this process. Beyond its role in the urea cycle, L-ornithine is also involved in the synthesis of other amino acids and polyamines, which are important for cell growth and proliferation. It is often used as a supplement to support athletic performance, reduce fatigue, and promote wound healing.
Key Benefits
Reduces Fatigue
By promoting the excretion of ammonia, L-ornithine may help reduce fatigue during exercise.
Supports Athletic Performance
Some studies suggest that L-ornithine supplementation can improve measures of athletic performance such as speed and power.
Promotes Wound Healing
Ornithine is a precursor to proline, an amino acid that is essential for collagen synthesis and wound healing.
Dosage & How to Take
Dosage can vary depending on the intended use. It is often taken in divided doses throughout the day.
| Purpose | Dose | Notes |
|---|---|---|
| Athletic Performance | 2-6 grams per day | Taken before exercise. |
| Ammonia Reduction | 3-6 grams per day | Taken in divided doses. |
Best Time to Take
For athletic performance, take 30-60 minutes before exercise. For general health, it can be taken at any time.
With or Without Food
Optional
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| L-Ornithine | High | General supplementation. | The free-form amino acid. |
| L-Ornithine HCL | High | Improved stability and solubility. | A salt form of L-ornithine. |
Side Effects & Safety
Common
- Nausea
- Stomach upset
- Diarrhea
Rare
- Insomnia
- Headaches
Contraindications
- Individuals with ornithine transcarbamylase deficiency should not take ornithine supplements.
Interactions
No significant interactions have been reported.
Scientific Research
L-ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism
L-ornithine has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia.
Effects of L-ornithine supplementation on growth hormone and insulin-like growth factor-1 in humans
L-ornithine supplementation can increase growth hormone levels.
Food Sources
Products With L-Ornithine
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.