L-5-Methyltetrahydrofolate (Quatrefolic)
The most bioactive and readily usable form of folate, essential for numerous bodily functions.
Also known as: 5-MTHF • L-Methylfolate • Active Folate
Overview
L-5-Methyltetrahydrofolate (5-MTHF), available as the branded ingredient Quatrefolic®, is the active, methylated form of folate. Unlike folic acid, it does not require conversion by the MTHFR enzyme, making it a highly bioavailable option for everyone, especially those with MTHFR gene mutations. It plays a critical role in methylation, DNA synthesis, and neurotransmitter production.
Key Benefits
Supports Healthy Methylation
As the primary methyl donor, 5-MTHF is crucial for countless metabolic processes, including DNA and RNA synthesis, and regulating gene expression.
Promotes Cardiovascular Health
Helps convert homocysteine into methionine, thus maintaining healthy homocysteine levels, which is a key factor for cardiovascular wellness.
Enhances Mood and Cognitive Function
5-MTHF is required for the synthesis of key neurotransmitters like serotonin, dopamine, and norepinephrine, which are vital for mood regulation and brain health.
Essential for Healthy Pregnancy
Crucial for preventing neural tube defects in the developing fetus and supporting overall maternal and fetal health.
Dosage & How to Take
Dosage varies based on individual needs, age, and health status. For general health, a dose of 400-1000 mcg is common. Higher doses may be used for specific conditions under medical supervision.
| Purpose | Dose | Notes |
|---|---|---|
| General Health & Wellness | 400-800 mcg | A standard dose for most adults. |
| Pregnancy Support | 600-1000 mcg | Higher intake is recommended before and during pregnancy. |
| Homocysteine Management | 800-5000 mcg | Higher doses may be required to effectively lower elevated homocysteine levels. |
Best Time to Take
Can be taken at any time of day.
With or Without Food
Can be taken with or without food, as it is well-absorbed either way.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| L-5-Methyltetrahydrofolate Glucosamine Salt (Quatrefolic®) | High | General use, individuals with MTHFR mutations | A highly stable and bioavailable form of 5-MTHF. |
| L-5-Methyltetrahydrofolate Calcium Salt | High | General supplementation | Another common, effective form of methylated folate. |
Side Effects & Safety
Common
- Generally well-tolerated. Some may experience mild digestive upset initially.
Rare
- Anxiety, irritability, insomnia, and skin rashes have been reported, particularly at higher doses.
Contraindications
- Should not be taken by individuals with a history of folate-sensitive cancers without consulting a healthcare professional.
Interactions
Folate may interfere with the antifolate activity of methotrexate. Use should be supervised by a doctor.
High doses of folate may decrease the serum levels of these drugs, potentially reducing their efficacy.
Folate can interfere with the effectiveness of this antimalarial drug.
Scientific Research
The role of 5-MTHF in depressive disorders
Supplementation with 5-MTHF has been shown to improve outcomes in patients with major depressive disorder, both as a standalone therapy and as an adjunct to antidepressants.
Folate and Cardiovascular Disease
Adequate folate status, best achieved with 5-MTHF, is associated with lower homocysteine levels and a reduced risk of cardiovascular events.
Quatrefolic® vs Folic Acid in Pregnant Women
Quatrefolic® was more effective than folic acid at increasing red blood cell folate levels, a key indicator of folate status and neural tube defect risk.
Food Sources
Products With L-5-Methyltetrahydrofolate (Quatrefolic)
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.