Hericenones
Bioactive compounds from Lion's Mane mushroom that stimulate Nerve Growth Factor (NGF) production.
Also known as: Hericium erinaceus compounds
Overview
Hericenones are a class of bioactive compounds found in the fruiting body of the Lion's Mane (Hericium erinaceus) mushroom. Along with erinacines (found in the mycelium), hericenones are known for their ability to cross the blood-brain barrier and stimulate the synthesis of Nerve Growth Factor (NGF), which is crucial for the growth, maintenance, and survival of neurons.
Key Benefits
Stimulates Nerve Growth Factor (NGF)
Hericenones are one of the few natural compounds shown to promote the production of NGF, supporting brain and nerve health.
Enhances Cognitive Function
By promoting neurogenesis, hericenones may help improve memory, focus, and overall cognitive performance.
Supports Nervous System Recovery
NGF plays a role in repairing damaged nerves, and hericenones may aid in recovery from nerve injuries.
Neuroprotective Properties
The antioxidant and anti-inflammatory effects of Lion's Mane compounds help protect brain cells from oxidative stress and damage.
Dosage & How to Take
There is no specific dosage for hericenones alone, as they are consumed as part of a whole Lion's Mane extract. Effective doses of Lion's Mane extract range from 500mg to 3000mg per day.
| Purpose | Dose | Notes |
|---|---|---|
| Cognitive Maintenance | 500-1000mg of Lion's Mane extract | Daily, standardized for active compounds. |
| Enhanced Focus | 1000-2000mg of Lion's Mane extract | Taken before mentally demanding tasks. |
| Nerve Support | 1500-3000mg of Lion's Mane extract | May be used under guidance of a health practitioner. |
Best Time to Take
Can be taken any time of day. Some prefer the morning for cognitive benefits throughout the day.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Lion's Mane Fruiting Body Extract | Good | Source of hericenones. | Look for extracts standardized for beta-glucans and hericenones. |
| Lion's Mane Mycelium Extract | Good | Source of erinacines. | Often grown on rice; some products contain high levels of starch. |
Side Effects & Safety
Common
- None reported in studies.
Rare
- Mild digestive discomfort in sensitive individuals
- Itchy skin (anecdotal, possibly related to NGF increase)
Contraindications
- Allergy to mushrooms.
Interactions
Lion's Mane may have mild blood-thinning properties; caution is advised.
Lion's Mane may lower blood sugar; monitor glucose levels closely.
Scientific Research
Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus
Compounds from Hericium erinaceus, including hericenones, have been shown to induce NGF synthesis in nerve cells.
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment
Supplementation with H. erinaceus extract improved cognitive function in older adults with mild cognitive impairment.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.