Cetyl Myristoleate
A unique esterified fatty acid that acts as a joint 'lubricant' and anti-inflammatory agent.
Also known as: CMO
Overview
Cetyl Myristoleate (CMO) is a compound that is a combination of myristoleic acid (a monounsaturated fatty acid) and cetyl alcohol. It was discovered by a researcher at the National Institutes of Health who found it protected mice from developing arthritis. The proposed mechanisms of action include acting as a surfactant or lubricant for joints, possessing anti-inflammatory properties, and modulating the immune system to reduce autoimmune responses that can affect joints.
Key Benefits
Joint Lubrication
The primary theory is that CMO helps to lubricate the joints and soft tissues, improving flexibility and reducing pain.
Anti-inflammatory Action
CMO may help to reduce inflammation by modulating prostaglandins and leukotrienes.
Immune System Modulation
It is thought to help regulate the immune system, which can be beneficial in autoimmune-related joint conditions like rheumatoid arthritis.
Dosage & How to Take
Doses range from 1000mg to 1500mg of a cetyl myristoleate complex per day, often in divided doses.
| Purpose | Dose | Notes |
|---|---|---|
| Osteoarthritis/Joint Pain | 350-500mg three times daily | Often taken for a loading period of 1-2 months. |
Best Time to Take
Take 30 minutes before meals for best absorption.
With or Without Food
No, take before meals.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Cetyl Myristoleate Complex | Moderate | General joint pain and lubrication. | Often combined with other supportive ingredients like glucosamine or sea buckthorn oil. |
Side Effects & Safety
Common
- Generally well-tolerated.
Rare
- Mild indigestion or burping.
Contraindications
- Not recommended for pregnant or breastfeeding women due to a lack of safety data.
Interactions
Scientific Research
Effects of a cetylated fatty acid topical cream on functional mobility and quality of life of patients with osteoarthritis
A topical cream with cetylated fatty acids improved functional mobility in patients with knee osteoarthritis.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.