Cascara Sagrada
A stimulant laxative herb used for short-term relief of constipation.
Also known as: Rhamnus purshiana • Sacred Bark
Overview
Cascara sagrada, which means 'sacred bark' in Spanish, is a shrub native to the Pacific Northwest of North America. The dried, aged bark of the plant has been used for centuries by Native American tribes as a natural laxative. It is classified as a stimulant laxative because it contains compounds called anthraquinones, which irritate the lining of the colon. This irritation stimulates muscle contractions (peristalsis) in the intestines, which helps to move stool through the bowel and promote a bowel movement. For many years, cascara sagrada was an FDA-approved over-the-counter (OTC) drug for constipation. However, in 2002, the FDA reclassified it, requiring that all OTC products containing it be reformulated or removed from the market due to a lack of modern safety data and concerns about its potential for long-term side effects. Today, it is sold exclusively as a dietary supplement. It is intended only for short-term use (no more than one week), as prolonged use can lead to dependence, electrolyte imbalances, and a poorly functioning bowel. It is crucial to use cascara sagrada with caution and under the guidance of a healthcare professional.
Key Benefits
Relieves Occasional Constipation
As a stimulant laxative, it effectively induces bowel movements by stimulating contractions in the colon.
Dosage & How to Take
Use the lowest effective dose for the shortest possible duration. Not for long-term use.
| Purpose | Dose | Notes |
|---|---|---|
| Constipation | 20-30 mg of active anthraquinones | This typically corresponds to about 300 mg of a standardized extract, taken once daily at bedtime. |
Best Time to Take
Take at bedtime. It usually takes 6-12 hours to produce an effect.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Capsules/Tablets | Medium | Standardized dosing. | Look for products made from aged bark (at least one year old) to reduce harshness. |
| Liquid Extract/Tincture | Medium | Adjustable dosing. | Can have a very bitter taste. |
Side Effects & Safety
Common
- Abdominal cramps
- Diarrhea
- Nausea
Rare
- Electrolyte imbalance (with long-term use)
- Liver damage (rare, but reported)
- Darkening of urine (harmless)
Contraindications
- Intestinal obstruction
- Crohn's disease
- Ulcerative colitis
- Appendicitis
- Abdominal pain of unknown origin
- Pregnancy and breastfeeding
- Children under 12
Interactions
Increases the risk of potassium loss and electrolyte imbalance.
Can increase potassium loss.
Low potassium levels can increase the risk of digoxin toxicity.
Scientific Research
Final rule establishing new requirements for over-the-counter (OTC) laxative drug products
The FDA ruled that cascara sagrada was not generally recognized as safe and effective for OTC use due to lack of sufficient data.
Food Sources
Products With Cascara Sagrada
2 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.