Calcium D-Glucarate
Supports the body's natural detoxification process, particularly Phase II liver detox.
Also known as: CDG
Overview
Calcium D-Glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by humans. It supports a crucial detoxification pathway in the liver called glucuronidation, which involves binding toxins and excess hormones to make them water-soluble for excretion.
Key Benefits
Enhances Phase II Detox
Inhibits the enzyme beta-glucuronidase, preventing toxins and hormones from being reabsorbed and ensuring their elimination.
Promotes Hormone Balance
By aiding the excretion of excess estrogens, it can help support healthy hormone balance in both men and women.
Supports Liver Health
Reduces the overall toxic load on the liver by ensuring efficient removal of harmful substances.
May Lower Cholesterol
Some studies suggest it may help maintain healthy cholesterol levels.
Dosage & How to Take
500mg taken 1-3 times per day.
| Purpose | Dose | Notes |
|---|---|---|
| General Detox Support | 500mg/day | |
| Hormone Balance/Estrogen Dominance | 1000-3000mg/day | Taken in divided doses with meals. |
Best Time to Take
Best taken with meals to coincide with the body's natural digestive and detoxification processes.
With or Without Food
Yes, recommended.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Calcium D-Glucarate | Good | Detox and hormone support | This is the standard and most researched form. |
Side Effects & Safety
Common
- Generally well-tolerated.
Rare
- None reported at standard doses.
Contraindications
- None known, but consult a doctor if pregnant, nursing, or on medication.
Interactions
Theoretically, it could increase the excretion of certain drugs, but this has not been well-documented in humans.
Scientific Research
Chemopreventive properties of D-glucarate
Animal and in-vitro studies show D-glucarate has potential cancer-preventive properties by promoting the detoxification of carcinogens.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.