Caffeine Anhydrous
A powerful central nervous system stimulant that enhances energy, focus, and athletic performance.
Also known as: 1,3,7-Trimethylxanthine
Overview
Caffeine Anhydrous is a dehydrated, highly concentrated form of caffeine. It is the most common form of caffeine used in sports supplements like pre-workouts and fat burners. It works by blocking adenosine receptors in the brain, which reduces drowsiness and leads to increased alertness, improved focus, and enhanced physical performance by reducing the perception of effort.
Key Benefits
Increases Energy & Alertness
Effectively combats drowsiness and fatigue by stimulating the central nervous system.
Enhances Athletic Performance
Proven to improve performance in both endurance and high-intensity activities by lowering the perceived effort.
Improves Mental Focus & Cognition
Can lead to better concentration, faster reaction time, and improved short-term memory.
Boosts Metabolic Rate
Increases thermogenesis and fat oxidation, which can aid in weight management.
Dosage & How to Take
Doses are highly individual and depend on tolerance. A typical dose is 3-6 mg per kg of bodyweight.
| Purpose | Dose | Notes |
|---|---|---|
| Performance Enhancement | 3-6 mg/kg | Taken 30-60 minutes before exercise. For a 70kg person, this is 210-420 mg. Do not exceed 400mg in a single dose. |
| Alertness/Focus | 100-200 mg | As needed to combat fatigue. Avoid taking late in the day to prevent sleep disruption. |
Best Time to Take
Peak plasma concentrations are reached around 60 minutes after ingestion.
With or Without Food
Taking with food may slightly delay absorption but can reduce the risk of jitteriness or stomach upset.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Anhydrous | Very High | Fast-acting, precise dosing in supplements. | The most common form in pills and powders. |
| Natural (from Coffee/Tea) | High | Daily consumption, provides other beneficial compounds. | Absorption rate can be slower. Content can be variable. |
Side Effects & Safety
Common
- Jitters, anxiety, rapid heartbeat, insomnia, and digestive upset are common, especially at higher doses.
Rare
- High doses can lead to caffeine toxicity, characterized by dizziness, severe nausea, heart palpitations, and in extreme cases, seizures.
Contraindications
- Individuals with anxiety disorders, heart conditions, or high blood pressure should be cautious. Pregnant women should limit intake.
Interactions
Caffeine can slow the clearance of theophylline, increasing its effects and side effects.
Combining with other stimulants significantly increases the risk of cardiovascular side effects.
Scientific Research
International society of sports nutrition position stand: caffeine and performance
The ISSN concludes that caffeine is an effective ergogenic aid for a wide range of sports and activities, with benefits seen at doses of 3-6 mg/kg.
Food Sources
Products With Caffeine Anhydrous
76 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.