Apoaequorin
A jellyfish-derived protein claimed to support brain health and improve memory.
Also known as: Prevagen
Overview
Apoaequorin is a calcium-binding protein originally discovered in the jellyfish *Aequorea victoria*. It is the main active ingredient in the popular brain health supplement, Prevagen. The theory behind its use is that it helps regulate intracellular calcium in brain cells, which may protect them from damage and support cognitive function. However, the scientific evidence supporting these claims is limited and controversial.
Key Benefits
Potential Cognitive Support
Proponents claim that apoaequorin can improve mild memory loss associated with aging by regulating calcium in brain cells.
Neuroprotective Properties
Theoretically, by binding to excess calcium, apoaequorin could protect neurons from excitotoxicity, a form of cell death caused by excessive stimulation.
Dosage & How to Take
The standard dose of apoaequorin used in studies and sold commercially is 10 mg per day. Higher doses are also available but their safety and efficacy have not been well-studied.
| Purpose | Dose | Notes |
|---|---|---|
| Mild Memory Loss | 10 mg/day | This is the dose used in the main clinical trial for Prevagen. |
| Moderate Memory Loss | 20-40 mg/day | Higher strength formulations are available, but evidence for their superiority is lacking. |
Best Time to Take
Can be taken at any time of day, with or without food.
With or Without Food
Not required, but can be taken with a meal if preferred.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Capsules | Unknown | Convenience and standard dosing. | The protein is likely digested in the stomach, raising questions about its ability to reach the brain intact. |
Side Effects & Safety
Common
- Headache
- Dizziness
- Nausea
Rare
- Constipation
- Edema (swelling)
- Hypertension (high blood pressure)
Contraindications
- There is not enough reliable information to know if apoaequorin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Interactions
There are no well-documented drug or supplement interactions with apoaequorin.
Scientific Research
The Madison Memory Study: A Randomized, Double-Blinded, Placebo-Controlled Trial of Apoaequorin in Community-Dwelling Older Adults
The study, funded by the manufacturer, found no statistically significant improvement in the overall study population, but claimed some benefit in a subgroup analysis of participants with milder cognitive impairment.
FTC and New York Attorney General Charge the Marketers of Prevagen with Making Deceptive Memory Improvement Claims
The Federal Trade Commission and the New York Attorney General filed a complaint alleging that the marketers of Prevagen made false and unsubstantiated claims about its effectiveness.
Food Sources
Products With Apoaequorin
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.