Agmatine
A metabolite of arginine that may support mood, pain, and athletic performance.
Also known as: (4-aminobutyl)guanidine
Overview
Agmatine is a compound that is naturally produced in the body from the amino acid arginine. It is found in various tissues and is thought to act as a neurotransmitter and neuromodulator. Agmatine has been studied for a wide range of potential benefits, including its ability to support mood, reduce pain, and enhance athletic performance. It is believed to work through multiple mechanisms, including its interaction with various receptors in the brain, its ability to modulate nitric oxide production, and its antioxidant properties. Research on agmatine is still in its early stages, but some studies suggest that it may be beneficial for conditions such as depression, neuropathic pain, and drug addiction. It has also gained popularity in the fitness community as a pre-workout supplement, with claims that it can improve muscle pumps and endurance. However, more research is needed to confirm these effects and to determine the optimal dosage and long-term safety of agmatine supplementation.
Key Benefits
May Improve Mood
Agmatine may have antidepressant-like effects by modulating various neurotransmitter systems in the brain.
May Reduce Pain
Some studies suggest that agmatine can help alleviate neuropathic pain by interacting with pain pathways.
May Enhance Athletic Performance
Agmatine may improve muscle pumps and endurance by increasing nitric oxide production.
Dosage & How to Take
Start with a low dose and assess tolerance. Consult with a healthcare professional before use.
| Purpose | Dose | Notes |
|---|---|---|
| Mood Support | 500-1000 mg per day | May be taken in divided doses. |
| Pain Relief | 1000-2670 mg per day | Higher doses may be needed for this purpose. |
| Athletic Performance | 500-1000 mg | Take 30-60 minutes before exercise. |
Best Time to Take
For athletic performance, take before workouts. For other benefits, it can be taken at any time of day.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Agmatine Sulfate | High | General use | The most common form of agmatine supplement. |
Side Effects & Safety
Common
- Nausea
- Diarrhea
- Stomach upset
Rare
- Headache
- Dizziness
Contraindications
- Individuals with kidney or liver disease should use with caution.
Interactions
May enhance the effects of these medications
May compete for absorption
Scientific Research
Agmatine enhances the antidepressant-like effects of selective serotonin reuptake inhibitors in mice
Agmatine may be a useful adjunct to antidepressant therapy.
Agmatine: a potential novel therapeutic agent for neuropathic pain
A review of studies suggesting agmatine may be effective in treating neuropathic pain.
Food Sources
Products With Agmatine
6 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.