Vinpocetine
A semi-synthetic compound from periwinkle that enhances cerebral blood flow and neuroprotection.
Also known as: Ethyl Apovincaminate • Cavinton
Overview
Vinpocetine is a semi-synthetic derivative of vincamine, an alkaloid found in the periwinkle plant (Vinca minor). It has been used in Europe for decades to treat cerebrovascular disorders. Vinpocetine enhances cerebral blood flow, improves oxygen and glucose utilization in the brain, and has neuroprotective and anti-inflammatory properties.
Key Benefits
Cerebral Blood Flow
Selectively increases blood flow to the brain without significantly affecting peripheral circulation.
Memory Enhancement
Improves memory and cognitive processing speed in clinical studies.
Neuroprotection
Protects neurons from excitotoxicity and oxidative damage.
Anti-Inflammatory
Inhibits PDE1 and reduces neuroinflammation.
Dosage & How to Take
5-30 mg daily in divided doses.
| Purpose | Dose | Notes |
|---|---|---|
| Cognitive enhancement | 5-10 mg 3x/day | With meals |
| Cerebrovascular support | 10 mg 3x/day | Under medical guidance |
Best Time to Take
With meals, divided into 2-3 doses.
With or Without Food
Yes, absorption improves with food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Tablets | Moderate (improved with food) | Standard use | Take with meals. |
| Capsules | Moderate | Convenience | Same bioavailability as tablets. |
Side Effects & Safety
Common
- Mild headache
- Dizziness
- Flushing
Rare
- GI upset
- Insomnia
Contraindications
- Pregnancy
- Bleeding disorders
- Upcoming surgery
Interactions
May enhance anticoagulant effects.
May enhance hypotensive effects.
Scientific Research
Vinpocetine and cognitive function
Systematic review showed improvements in cognitive function and cerebral blood flow in patients with cerebrovascular disease.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.