Uridine Monophosphate
A nucleotide that supports synaptic plasticity, membrane synthesis, and dopamine function.
Also known as: UMP • Uridine-5'-monophosphate
Overview
Uridine monophosphate (UMP) is a pyrimidine nucleotide involved in RNA synthesis and phospholipid production. It crosses the blood-brain barrier and supports the synthesis of CDP-choline, a precursor to phosphatidylcholine — a major component of neuronal membranes. Uridine also modulates dopamine release and may enhance synaptic plasticity.
Key Benefits
Neuronal Membrane Synthesis
Provides building blocks for phosphatidylcholine, essential for healthy neuronal membranes.
Synaptic Plasticity
Supports the formation of new synaptic connections and dendritic spines.
Dopamine Modulation
May enhance dopamine release and receptor sensitivity.
Synergy with Choline
Works synergistically with choline sources and DHA for brain health.
Dosage & How to Take
150-500 mg daily.
| Purpose | Dose | Notes |
|---|---|---|
| General nootropic | 150-250 mg/day | With choline source |
| Enhanced cognitive support | 250-500 mg/day | Stack with DHA and choline |
Best Time to Take
Morning.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Capsules | Good | Standard use | Most common form. |
| Sublingual | High | Enhanced absorption | Bypasses first-pass metabolism. |
Side Effects & Safety
Common
- Generally well tolerated
Rare
- Mild GI discomfort
- Headache
Contraindications
- None well-established
Interactions
Generally compatible with other nootropics.
Scientific Research
Uridine and brain phospholipid synthesis
Animal studies showed uridine supplementation increased brain phosphatidylcholine levels and synaptic membrane formation.
Food Sources
Products With Uridine Monophosphate
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.