Type II Collagen
The primary collagen in cartilage, crucial for joint structure and function.
Also known as: UC-II • Undenatured Type II Collagen
Overview
Type II Collagen is a specific type of collagen that is the main component of cartilage in the body. Unlike other types of collagen, undenatured Type II Collagen (UC-II) is thought to work through a process called oral tolerization, where it interacts with the immune system in the gut to reduce inflammation in the joints, rather than by directly providing building blocks for cartilage.
Key Benefits
Reduces Joint Pain
Studies show it can significantly decrease joint pain in individuals with osteoarthritis and rheumatoid arthritis.
Improves Joint Function
Helps improve knee extension and overall joint function, making daily activities easier.
Modulates Immune Response
Works by preventing the immune system from attacking the body's own collagen in the joints, thus reducing inflammation.
Dosage & How to Take
A standard dose of 40mg of undenatured Type II Collagen is recommended.
| Purpose | Dose | Notes |
|---|---|---|
| Osteoarthritis Support | 40mg/day | Taken once daily. |
| Rheumatoid Arthritis Support | 40mg/day | May help reduce joint swelling and tenderness. |
Best Time to Take
Best taken on an empty stomach before bed to optimize immune interaction in the gut.
With or Without Food
Not required.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Undenatured Type II Collagen (UC-II®) | High (due to its mechanism of action) | Joint inflammation and autoimmune-related joint issues. | This is the clinically studied form. |
| Hydrolyzed Type II Collagen | Moderate | Providing collagen building blocks. | Works differently than the undenatured form. |
Side Effects & Safety
Common
- Generally well-tolerated.
Rare
- Mild digestive upset.
Contraindications
- Individuals with allergies to chicken, as it's often sourced from chicken sternum.
Interactions
Scientific Research
Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study
UC-II was well tolerated and demonstrated better efficacy compared to placebo in modulating knee osteoarthritis symptoms.
Food Sources
Products With Type II Collagen
4 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.