Tributyrin
A superior butyrate delivery system that reaches the colon intact for gut barrier support.
Also known as: Glyceryl Tributyrate • Butyrate Prodrug
Overview
Tributyrin is a triglyceride form of butyric acid that provides a more stable and targeted delivery of butyrate to the colon compared to sodium butyrate. Butyrate is the primary fuel source for colonocytes and plays a critical role in maintaining gut barrier integrity, reducing inflammation, and supporting a healthy microbiome.
Key Benefits
Gut Barrier Integrity
Butyrate strengthens tight junctions between intestinal cells, reducing intestinal permeability.
Anti-Inflammatory
Inhibits NF-kB and reduces pro-inflammatory cytokines in the gut lining.
Microbiome Support
Creates a favorable environment for beneficial bacteria to thrive.
Colon Health
Primary energy source for colonocytes, supporting healthy cell turnover.
Dosage & How to Take
300-1000 mg daily.
| Purpose | Dose | Notes |
|---|---|---|
| Gut maintenance | 300-500 mg/day | With meals |
| Therapeutic gut support | 500-1000 mg/day | Split into 2-3 doses |
Best Time to Take
With meals.
With or Without Food
Yes, with food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Delayed-Release Capsules | High (targeted) | Colon delivery | Reaches lower GI intact. |
| Standard Capsules | Moderate | Upper GI support | Some absorption in small intestine. |
Side Effects & Safety
Common
- Mild GI discomfort initially
- Butyric acid odor
Rare
- Nausea at high doses
Contraindications
- Active IBD flare (consult doctor)
Interactions
Generally well tolerated with other supplements.
Scientific Research
Tributyrin and gut barrier function
Studies showed improved intestinal barrier integrity and reduced markers of intestinal permeability.
Food Sources
Products With Tributyrin
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.