Strontium Citrate
A unique mineral that supports bone density by both stimulating bone-building cells and inhibiting bone-resorbing cells.
Also known as: Strontium
Overview
Strontium is a trace mineral that is chemically similar to calcium and is found in bones and teeth. Strontium citrate is a supplemental form of this mineral. Research, primarily on the prescription form strontium ranelate, has shown that strontium has a dual mechanism of action on bone health. It stimulates osteoblasts (cells that build bone) and inhibits osteoclasts (cells that break down bone), leading to a net increase in bone mineral density.
Key Benefits
Increases Bone Density
Stimulates the replication of pre-osteoblastic cells, leading to increased bone formation.
Reduces Bone Resorption
Inhibits the differentiation and activity of osteoclasts, the cells responsible for bone breakdown.
Lowers Fracture Risk
Clinical trials with strontium ranelate have demonstrated a significant reduction in both vertebral and non-vertebral fractures in postmenopausal women with osteoporosis.
Dosage & How to Take
The standard dose is 680mg of elemental strontium, taken once daily.
| Purpose | Dose | Notes |
|---|---|---|
| Osteoporosis/Osteopenia | 680mg elemental strontium/day | Must be taken on an empty stomach, at least 2 hours apart from calcium supplements or calcium-rich meals. |
Best Time to Take
Best taken at bedtime, on an empty stomach, and several hours after any calcium intake.
With or Without Food
No, take on an empty stomach.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Strontium Citrate | Good | Over-the-counter bone density support. | The most common form in supplements. |
| Strontium Ranelate | Good | Prescription treatment for osteoporosis (not available in all countries). | The form used in most clinical trials. |
Side Effects & Safety
Common
- Nausea, diarrhea (usually transient).
Rare
- Increased risk of venous thromboembolism (blood clots) and cardiovascular events has been noted with strontium ranelate, though the risk is small.
Contraindications
- Individuals with a history of blood clots, heart attack, or stroke. Severe kidney disease.
Interactions
Competes for absorption, reducing the effectiveness of both minerals.
Strontium can reduce the absorption of these antibiotics.
Scientific Research
Strontium ranelate: a novel treatment for postmenopausal osteoporosis with a dual mode of action
Strontium ranelate was shown to both increase bone formation and decrease bone resorption, leading to a net gain in bone mass and reduced fracture risk.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.