St. John's Wort
A well-researched herb for mild to moderate depression, but with significant drug interactions.
Also known as: Hypericum perforatum • Klamath weed
Overview
St. John's Wort is a flowering plant that has been used for centuries to treat nerve pain and mood disorders. Its active constituents, primarily hypericin and hyperforin, are believed to work by increasing the levels of several neurotransmitters in the brain, including serotonin, dopamine, and norepinephrine. It is one of the most studied herbal remedies for depression.
Key Benefits
Treats Mild to Moderate Depression
Numerous studies have found St. John's Wort to be as effective as standard antidepressant medications for mild to moderate depression, with fewer side effects.
Eases Anxiety
It can also have a calming effect, helping to reduce symptoms of anxiety and nervousness.
May Help with PMS and Menopause Symptoms
Some research suggests it can alleviate the psychological and physical symptoms of PMS and menopause.
Dosage & How to Take
The standard dosage is 300mg of a standardized extract taken three times daily.
| Purpose | Dose | Notes |
|---|---|---|
| Depression | 900mg/day | Split into three 300mg doses. |
| Anxiety/PMS | 300-900mg/day | Start with a lower dose and adjust as needed. |
Best Time to Take
Best taken in divided doses with meals throughout the day.
With or Without Food
Yes, taking it with food can help prevent gastrointestinal side effects like nausea.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Extract (Capsules/Tablets) | High | Depression | Ensure the product is standardized to 0.3% hypericin and/or 2-5% hyperforin. |
| Tea/Tincture | Variable | Mild stress | Dosage is less consistent and may be less effective. |
Side Effects & Safety
Common
- Stomach upset
- Dry mouth
- Dizziness
- Fatigue
- Photosensitivity (increased sun sensitivity)
Rare
- Anxiety
- Sexual dysfunction
- Psychosis (in rare cases)
Contraindications
- Pregnancy and breastfeeding
- Bipolar disorder
- Schizophrenia
- Upcoming surgery
Interactions
High risk of serotonin syndrome.
Can reduce the effectiveness of oral contraceptives.
Reduces effectiveness, increasing risk of clots.
Induces liver enzymes (CYP3A4), accelerating the metabolism of numerous drugs.
Scientific Research
St John's wort for major depression.
St John's wort extracts are more effective than placebo and similarly effective as standard anti-depressants for major depression.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.