Procyanidin B2
A potent antioxidant polyphenol found in apples that has been shown to stimulate hair growth in clinical research.
Also known as: Apple Procyanidin B2 • Proanthocyanidin B2
Overview
Procyanidin B2 is a type of proanthocyanidin, a class of flavonoid antioxidants found in many plants, most notably in unripe apples, grapes, and cinnamon. Research from Japan in the late 1990s and early 2000s identified Procyanidin B2 as a potent hair growth-stimulating compound. It is thought to work by promoting the anagen (growth) phase of the hair cycle and protecting hair follicle cells from oxidative stress. Both topical and oral administration have been studied, showing increases in hair diameter and density.
Key Benefits
Promotes Anagen Phase Induction
Procyanidin B2 has been shown to promote the transition of hair follicles from the resting (telogen) phase to the active growth (anagen) phase.
Increases Hair Diameter
Studies have noted an increase in the thickness of individual hair strands, contributing to fuller-looking hair.
Potent Antioxidant
It protects the hair follicle cells from damage caused by free radicals and environmental stressors, creating a healthier environment for growth.
Dosage & How to Take
Most research has been conducted using specific extracts.
| Purpose | Dose | Notes |
|---|---|---|
| Topical Hair Growth Treatment | 1% Procyanidin B2 solution applied to the scalp | Applied once or twice daily. This was the concentration used in several key studies. |
| Oral Supplementation | Around 300mg/day of an apple polyphenol extract | Oral use has also shown benefits for hair and overall antioxidant support. |
Best Time to Take
Topical applications should be applied to a clean, dry scalp. Oral supplements are best taken with food.
With or Without Food
Yes (for oral supplements).
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Standardized Apple Polyphenol Extract | Good | Oral or topical use. | Look for extracts specifically standardized for their procyanidin B2 content. |
| Topical Solution | N/A (topical) | Direct application to the scalp. | Often found in specialized hair growth serums. |
Side Effects & Safety
Common
- Generally none. Well-tolerated in studies.
Rare
- Mild scalp irritation from topical products in sensitive individuals.
Contraindications
- Allergy to apples.
Interactions
No significant drug interactions have been reported.
Scientific Research
Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory and clinical study
A 2000 study demonstrated that Procyanidin B-2 acts as a hair-growth-stimulating agent in mice and that a 1% topical solution increased the number of total hairs and terminal hairs in human subjects.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.