Nitrosigine®
A patented complex of arginine and silicon that boosts nitric oxide levels for up to 6 hours.
Also known as: Inositol-Stabilized Arginine Silicate • ASI
Overview
Nitrosigine® is a patented ingredient that bonds L-arginine with inositol and potassium silicate. This unique complex is designed to significantly enhance nitric oxide (NO) levels, a key factor in promoting blood flow to working muscles. Unlike standard L-arginine, Nitrosigine is more bioavailable and has been shown in clinical studies to start working within 15 minutes and keep NO levels elevated for up to 6 hours after a single dose.
Key Benefits
Sustained Nitric Oxide Boost
Elevates nitric oxide levels for a prolonged period (up to 6 hours), much longer than traditional L-arginine or citrulline.
Improves Muscle Pump
By increasing blood flow, it enhances the delivery of oxygen and nutrients to muscles, leading to a better muscle pump during workouts.
Enhances Cognitive Function
Studies show that Nitrosigine can improve processing speed and cognitive flexibility, both before exercise and after strenuous activity.
Reduces Muscle Damage
Pre-clinical studies suggest it can help reduce markers of muscle damage (like creatine kinase) after exercise, potentially speeding up recovery.
Dosage & How to Take
The clinically studied and effective dose is 1,500 mg per day.
| Purpose | Dose | Notes |
|---|---|---|
| Pre-Workout Performance | 1,500 mg | Take 15-30 minutes before training for optimal effects on blood flow and focus. |
| Cognitive Enhancement | 750 - 1,500 mg | Can be taken daily to support cognitive function, even on non-training days. |
Best Time to Take
For best results, take 15-30 minutes prior to your workout.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Nitrosigine® (Patented Complex) | High | Pre-workout vasodilation and cognitive focus. | This is a specific, patented ingredient and not a generic mixture. |
Side Effects & Safety
Common
- Extremely well-tolerated with no significant common side effects reported in clinical studies at the recommended dose.
Rare
- No rare side effects have been documented.
Contraindications
- As with other NO boosters, individuals on blood pressure medication or nitrates should consult a doctor before use.
Interactions
May potentiate the effects of medications that lower blood pressure.
Scientific Research
A clinical evaluation to determine the safety, pharmacokinetics, and pharmacodynamics of an inositol-stabilized arginine silicate dietary supplement in healthy adult males
A single 1500mg dose of Nitrosigine significantly increased plasma arginine levels for 6 hours and nitric oxide levels for up to 3 hours. It was found to be safe and well-tolerated.
Food Sources
Products With Nitrosigine®
5 products in our database contain this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.