Nickel
An ultra-trace element with possible roles in iron metabolism and enzyme function.
Also known as: Ni • Nickel Sulfate
Overview
Nickel is an ultra-trace element present in small amounts in the human body. While its exact biological role in humans is not fully established, animal studies suggest nickel may play roles in iron absorption, enzyme function, and lipid metabolism. Nickel deficiency in animals leads to impaired growth and altered iron metabolism. However, nickel supplementation is not recommended due to the high prevalence of nickel allergy and the lack of established human requirements.
Key Benefits
Possible Iron Metabolism Role
Animal studies suggest nickel may play a role in iron absorption and utilization, but this has not been confirmed in humans.
Dosage & How to Take
No recommended supplemental dose. Dietary intake of 25-35 mcg/day is typical.
| Purpose | Dose | Notes |
|---|---|---|
| Not recommended | N/A | Adequate amounts obtained from diet |
Best Time to Take
Not applicable.
With or Without Food
Not applicable.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Not recommended for supplementation | N/A | N/A | Nickel is a common contact allergen and supplementation is not advised. |
Side Effects & Safety
Common
- Allergic contact dermatitis (very common)
Rare
- Systemic nickel allergy
- GI distress
Contraindications
- Nickel allergy
- Eczema
- Dermatitis
Interactions
Nickel may compete with iron for absorption.
Scientific Research
Nickel in human nutrition
Review concluded that while nickel has biological activity in animals, its essentiality in humans remains unproven.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.