NADH
The reduced form of NAD+ that directly fuels mitochondrial energy production.
Also known as: Nicotinamide Adenine Dinucleotide (Reduced) • Coenzyme 1 • Enada
Overview
NADH (nicotinamide adenine dinucleotide, reduced form) is a coenzyme found in all living cells. It is the primary electron carrier in the mitochondrial electron transport chain, directly driving ATP production. NADH also participates in over 200 enzymatic reactions and plays roles in DNA repair, gene expression, and cellular signaling.
Key Benefits
ATP Production
Directly donates electrons to Complex I of the electron transport chain for ATP synthesis.
Cognitive Function
Supports brain energy metabolism and neurotransmitter production.
Fatigue Reduction
Clinical studies show improvement in chronic fatigue syndrome symptoms.
Cellular Repair
Supports DNA repair enzymes and cellular maintenance processes.
Dosage & How to Take
5-20 mg daily.
| Purpose | Dose | Notes |
|---|---|---|
| General energy | 5-10 mg/day | Sublingual, morning |
| Chronic fatigue | 10-20 mg/day | On empty stomach |
Best Time to Take
Morning on empty stomach, 30 minutes before food.
With or Without Food
No, take on empty stomach for best absorption.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| Sublingual Tablets | High | Bypasses digestive degradation | Dissolve under tongue. |
| Enteric-Coated Tablets | Moderate | Those who prefer swallowing | Protected from stomach acid. |
Side Effects & Safety
Common
- Generally well tolerated
Rare
- Mild anxiety or overstimulation
- Insomnia
Contraindications
- None well-established
Interactions
Compatible with other energy supplements.
Scientific Research
NADH and chronic fatigue syndrome
RCT showed 31% of CFS patients responded to NADH supplementation vs 8% placebo.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.