Methylsulfonylmethane
A sulfur-containing compound that supports joint health, reduces inflammation, and promotes healthy skin and hair.
Also known as: MSM
Overview
Methylsulfonylmethane, more commonly known as MSM, is an organic sulfur-containing compound that has gained popularity as a dietary supplement. It is found naturally in some plants, animals, and humans, and can also be produced in a lab. MSM is believed to deliver sulfur to the body in a usable way, which is important for the synthesis of collagen, glucosamine, and chondroitin – all essential components of cartilage and connective tissue. This has made MSM a popular supplement for supporting joint health and reducing the pain and inflammation associated with osteoarthritis. In addition to its benefits for joints, MSM is also thought to have anti-inflammatory and antioxidant properties that may help to reduce muscle damage and soreness after exercise. Furthermore, MSM is often included in beauty supplements for its purported ability to improve the health and appearance of skin, hair, and nails by donating sulfur for the production of keratin.
Key Benefits
Reduces Joint Pain and Inflammation
MSM may help to reduce pain and inflammation in individuals with osteoarthritis and other joint conditions.
Improves Skin, Hair, and Nail Health
By providing sulfur for keratin production, MSM may help to strengthen hair and nails and improve skin health.
Aids in Post-Exercise Recovery
MSM's anti-inflammatory properties may help to reduce muscle soreness and damage after intense exercise.
Dosage & How to Take
Start with a lower dose and gradually increase to assess tolerance. Doses are often divided throughout the day.
| Purpose | Dose | Notes |
|---|---|---|
| Joint Health | 1-3 grams, 2-3 times daily | Often taken in combination with glucosamine and chondroitin. |
| Skin and Hair Health | 1-3 grams daily | May take several weeks to see noticeable results. |
Best Time to Take
Best taken with meals to improve absorption and reduce the risk of digestive upset.
With or Without Food
Recommended to be taken with food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| MSM Powder | High | Flexible dosing and for those who prefer to mix it with liquids. | Can have a slightly bitter taste. |
| MSM Capsules | High | Convenient and tasteless option. | Available in various dosages. |
Side Effects & Safety
Common
- Nausea
- Diarrhea
- Bloating
- Stomach discomfort
Rare
- Headache
- Fatigue
- Insomnia
Contraindications
- Individuals with a sulfur allergy should avoid MSM.
Interactions
May have a mild blood-thinning effect and should be used with caution.
Scientific Research
Efficacy of methylsulfonylmethane (MSM) in osteoarthritis of the knee: a pilot clinical trial
MSM produced significant decreases in pain and physical function impairment in patients with osteoarthritis of the knee.
The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility
MSM supplementation may be effective in reducing pain and improving physical function in patients with osteoarthritis.
Food Sources
Products With Methylsulfonylmethane
1 product in our database contains this ingredient
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.