Methylene Blue
A mitochondrial enhancer and neuroprotectant with a century-long medical history.
Also known as: Methylthioninium Chloride • MB
Overview
Methylene blue is a synthetic compound first synthesized in 1876. It has a long history in medicine as a treatment for methemoglobinemia and malaria. At low doses, it acts as an electron carrier in the mitochondrial electron transport chain, enhancing cellular energy production. Research suggests neuroprotective properties and potential cognitive benefits through improved mitochondrial function and reduced oxidative stress.
Key Benefits
Mitochondrial Enhancement
Acts as an alternative electron carrier, bypassing complex I and III deficiencies.
Neuroprotection
Reduces tau aggregation and may slow neurodegeneration.
Cognitive Enhancement
Low doses may improve memory consolidation and recall.
Antioxidant
Cycles between oxidized and reduced forms, neutralizing free radicals.
Dosage & How to Take
0.5-2 mg/kg body weight daily.
| Purpose | Dose | Notes |
|---|---|---|
| Nootropic/mitochondrial | 0.5-1 mg/kg/day | Low dose is key |
| Research doses | 1-2 mg/kg/day | Under medical supervision |
Best Time to Take
Morning.
With or Without Food
Can be taken with or without food.
Forms & Bioavailability
| Form | Absorption | Best For | Notes |
|---|---|---|---|
| USP-Grade Liquid | High | Precise dosing | Must be pharmaceutical grade, not industrial. |
| Capsules | Good | Convenience | Ensure USP-grade source. |
Side Effects & Safety
Common
- Blue-green urine and stool (harmless)
- Blue discoloration of mouth
Rare
- Serotonin syndrome (with SSRIs)
- Hemolytic anemia in G6PD deficiency
Contraindications
- G6PD deficiency
- SSRI/SNRI use
- MAOI use
- Pregnancy
- Renal impairment
Interactions
Risk of serotonin syndrome — CONTRAINDICATED.
Methylene blue has MAOI activity — CONTRAINDICATED.
Scientific Research
Methylene blue and memory
Low-dose methylene blue improved memory retention in healthy subjects by enhancing mitochondrial function in brain regions involved in memory.
Food Sources
Frequently Asked Questions
Medical Disclaimer
This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.