Lactoferrin

Iron-binding protein with powerful antimicrobial and immune-balancing properties.

Also known as: Apolactoferrin • Bovine Lactoferrin

other Names
LF
primary Benefits
Antimicrobial, antiviral, immune regulation
common Dose
200-400 mg daily
best Form
Apolactoferrin (iron-free form) or freeze-dried bovine lactoferrin
timing
Best taken on an empty stomach
safety Rating
Very safe, derived from milk

Overview

Lactoferrin is a glycoprotein found in milk, tears, and other bodily secretions. It plays a crucial role in the innate immune system by binding to iron, which deprives bacteria of a key nutrient needed for growth, and by directly modulating immune cell activity.

Key Benefits

Inhibits Pathogen Growth

Binds to free iron, making it unavailable to pathogenic bacteria, viruses, and fungi that require it for replication.

Antiviral Activity

Can block viruses from entering host cells and enhance the body's antiviral response.

Modulates Immune Function

Can both stimulate the immune system when needed and reduce inflammation, helping to maintain immune balance.

Dosage & How to Take

200-400 mg per day is a common dosage for general immune support.

PurposeDoseNotes
Daily Immune Maintenance200 mg/dayOften taken in divided doses.
Acute Infection400-600 mg/dayHigher doses may be used for short-term support.

Best Time to Take

Take at least 30 minutes before meals for optimal absorption.

With or Without Food

Should be taken without food, as proteins in food can interfere with its function.

Forms & Bioavailability

FormAbsorptionBest ForNotes
Bovine LactoferrinGoodGeneral immune supportMost common form, derived from cow's milk.
ApolactoferrinHighMaximum iron-binding capacityThe iron-free form, which may have stronger antimicrobial effects.

Side Effects & Safety

Common

  • Extremely well-tolerated.

Rare

  • High doses (>1g/day) may cause digestive upset like cramping or diarrhea.

Contraindications

  • Individuals with a severe milk allergy should avoid it.

Interactions

Scientific Research

2017Journal of Leukocyte Biology

The effect of lactoferrin on the immune system

Lactoferrin demonstrates a wide range of effects on the immune system, including antibacterial, antiviral, and anti-inflammatory properties.

Food Sources

Cow's milk (especially colostrum)
Human breast milk
Cheese

Products With Lactoferrin

2 products in our database contain this ingredient

Frequently Asked Questions

Medical Disclaimer

This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.