L-Lysine

An essential amino acid that is important for growth, tissue repair, and the production of antibodies.

Also known as: Lysine

other Names
Lysine
primary Benefits
Cold sore prevention, anxiety reduction, bone health
common Dose
1-3 grams per day
best Form
Capsules or tablets
timing
Can be taken anytime, but often taken on an empty stomach
safety Rating
Generally Safe

Overview

L-lysine is an essential amino acid, which means that the body cannot produce it on its own and must obtain it from food or supplements. It is a building block for protein and is essential for proper growth and tissue repair. L-lysine is also involved in the production of carnitine, a substance that is important for fat metabolism, and collagen, a protein that is a major component of skin, bones, and connective tissues. One of the most well-known uses of L-lysine is for the prevention and treatment of cold sores, which are caused by the herpes simplex virus. L-lysine is thought to work by blocking the activity of arginine, an amino acid that the herpes virus needs to replicate. L-lysine has also been studied for its potential to reduce anxiety and support bone health.

Key Benefits

Prevents and Treats Cold Sores

May help to reduce the frequency and severity of cold sore outbreaks.

Reduces Anxiety

Some research suggests that L-lysine may help to reduce anxiety by affecting serotonin levels in the brain.

Supports Bone Health

L-lysine helps the body absorb calcium and is important for the formation of collagen, which is essential for bone health.

Dosage & How to Take

The dosage of L-lysine can vary depending on the individual and their health goals.

PurposeDoseNotes
Cold Sore Prevention1 gram per dayMay be increased to 3 grams per day during an outbreak.
Anxiety Reduction2-3 grams per dayMay be taken in divided doses.

Best Time to Take

Can be taken at any time of day, but is often taken on an empty stomach for better absorption.

With or Without Food

Can be taken with or without food.

Forms & Bioavailability

FormAbsorptionBest ForNotes
CapsulesHighConvenient and precise dosingAvailable in various strengths.
TabletsHighConvenient and precise dosingAvailable in various strengths.

Side Effects & Safety

Common

  • Stomach pain
  • Diarrhea
  • Nausea

Rare

  • Kidney problems (with very high doses)

Contraindications

  • Individuals with kidney disease should consult a healthcare provider before use.

Interactions

None knownNone

No significant interactions reported.

Scientific Research

2017Integrative Medicine: A Clinician's Journal

Lysine for the prevention of herpes simplex

A review of studies found that L-lysine supplementation may be effective for preventing recurrent herpes simplex infections.

2007Biomedical Research

The effect of L-lysine on anxiety

Some studies have shown that L-lysine can help to reduce anxiety and stress.

Food Sources

Meat
Fish
Eggs
Dairy products
Legumes
Quinoa

Products With L-Lysine

5 products in our database contain this ingredient

Frequently Asked Questions

Medical Disclaimer

This content is for educational and informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare professional before starting any supplement regimen, especially if you have pre-existing health conditions or are taking medications. The statements on this page have not been evaluated by the Food and Drug Administration.